Nā huahana

ʻO ka 2,3-Difluoro-4-ethoxybenzeneboronic acid ka mea e loaʻa ai ka pono ma kekahi mau ʻano o ka kemika, ʻoi loa i ka synthesis organik a me ka lāʻau lapaʻau.Me kona hanana kūikawā a me ka reactivity, ua lilo ia i hale kūkulu waiwai no ka hana ʻana i nā molekala organik paʻakikī a me nā pūhui lāʻau lapaʻau.ʻO nā hopena hoʻohui keʻa, e like me nā hui Suzuki-Miyaura a me Buchwald-Hartwig, he mau ala ikaika no ke kūkulu ʻana i nā paʻa kalapona a me ka carbon heteroatom.I loko o kēia mau hopena, hiki i ka 2,3-Difluoro-4-ethoxybenzeneboronic acid ke lawelawe ma ke ʻano he ʻāpana ester boronate, e pane ana me nā electrophiles like ʻole (e laʻa, aryl halides, vinyl halides) ma lalo o ka mana o nā catalysts kūpono.ʻO kēia ka mea e hiki ai i ka synthesis o nā pūhui like ʻole me nā waiwai biologically active, e like me nā lāʻau lapaʻau a i ʻole agrochemical.Hiki i ka hoʻololi ʻana o Fluorine ke hoʻonui i ka paʻa, lipophilicity, a me ka pharmacokinetic profile o nā mea hoʻohuihui, e hoʻolilo iā lākou i mau moho lāʻau lapaʻau maikaʻi.No laila, ʻo ka hoʻohana ʻana i ka 2,3-Difluoro-4-ethoxybenzeneboronic acid ma ke ʻano he precursor i ka synthesis o nā pūhui lāʻau e like me ka lāʻau hiki ke hāʻawi i ke komo i nā molekala fluorinated me ka hoʻomaikaʻi ʻana i ka hana biological a me nā waiwai physicochemical makemake. Hāʻawi ka 3-Difluoro-4-ethoxybenzeneboronic acid i ka versatility hou i nā noi synthetic.Hiki ke hoʻopili ʻia i nā hopena nucleophilic substitution, e ʻae ana i ka hoʻokomo ʻana i nā pūʻulu hana like ʻole ma ke kūlana ethoxy.ʻO kēia ka mea e hiki ai i ka derivatization o ka pūhui ke hoʻololi i kāna mau waiwai no nā kumu kikoʻī a i ʻole e hoʻolauna i nā kikoʻī hou aku o ka ʻokoʻa i ka synthesis hale waihona no ka ʻike ʻana i ka lāʻau. lāʻau kemika.ʻO kona komo ʻana i nā hopena cross-coupling, hoʻohui ʻia o nā ʻātoma fluorine, a me ka derivatization ma ke kūlana ethoxy e lilo ia i mea waiwai nui no ke kūkulu ʻana i nā pūhui organik like ʻole me nā noi lāʻau lapaʻau.Hiki i kāna hoʻohana ke hoʻohui i nā molekala paʻakikī a me nā hale waihona puke no ka ʻike ʻana i ka lāʻau lapaʻau a hāʻawi i ke komo i nā pūhui fluorinated me nā waiwai i hoʻomaikaʻi ʻia.