Nā huahana

ʻO 3-tert-Butoxycarbonylphenylboronic acid, i ʻike ʻia ʻo Boc-phenylboronic acid, he mea waiwai nui ka boronic acid derivative me nā noi koʻikoʻi i ka synthesis organik a me nā kemika lāʻau lapaʻau. hoʻohuihui.Hoʻohana mau ʻia ka pūʻulu tert-butyloxycarbonyl (BOC) no ka pale ʻana i nā pūʻulu hana amine i ka wā o nā hopena like ʻole.Ma ka hoʻopili ʻana i ka pūʻulu BOC i ka moiety amine, ua hoʻemi ʻia ka reactivity o ka amine, e ʻae ana i nā hopena koho ma nā kūlana ʻē aʻe ma ka mole.Hiki ke wehe maʻalahi ka hui BOC ma lalo o nā kūlana haʻahaʻa, no laila e hōʻike ana i ka hana amine kumu.ʻO kēia hoʻolālā pūʻulu pale e hiki ai ke hoʻohui maikaʻi i nā molekala organik paʻakikī, e like me nā lāʻau lapaʻau a me nā huahana kūlohelohe.ʻO nā waikawa Boronic, me ka Boc-phenylboronic acid, hiki ke hana i nā esters boronate ke hoʻopili ʻia me nā nucleophiles, e like me nā waiʻona a i ʻole nā ​​amine.Hiki i kēia mau esters boronate ke hoʻololi i nā ʻano hoʻololi like ʻole, e like me Suzuki-Miyaura cross-coupling reactions, Negishi couplings, a me Stille couplings.Hiki i kēia mau hopena ke hoʻokumu i nā molekala organik paʻakikī me nā ʻano hoʻololi like ʻole a me nā pūʻulu hana.Pono pono ka waika Boc-phenylboronic no ka hoʻokomo ʻana i ka ʻāpana phenylboronic acid i loko o nā molekele.Hiki i ka hana ʻana o ka waika boronic ke launa pū me nā diols a i ʻole boronate ester-sensitive pūʻulu hana i loko o nā pahuhopu olaola, e hiki ai ke hoʻolālā i nā mea hoʻopaneʻe enzyme e pili ana i ka boronate a me nā ligand receptor.Hiki ke hoʻohui ʻia ka waikawa Boc-phenylboronic i loko o nā mea hoʻopaneʻe liʻiliʻi, peptides, a i ʻole prodrugs e hāʻawi i nā waiwai i makemake ʻia a i ʻole e hoʻonui i ka kikoʻī kikoʻī.Ua hōʻike ʻia kēia mau pūhui boronate i ka mālama ʻana i nā maʻi like ʻole, e like me ka maʻi kanesa, ka maʻi diabetes, a me ka mumū.ʻO kāna hui BOC he pūʻulu pale, e ʻae ana i nā hopena koho i nā kūlana ʻē aʻe ma ka mole.Eia kekahi, hiki i ka hana boronic acid ke hoʻokumu i ka hoʻokumu ʻana i ka carbon-carbon bond, e hoʻomaʻamaʻa i ka synthesis o nā molekala organik paʻakikī.Eia hou, he kuleana koʻikoʻi ka ʻakika Boc-phenylboronic i ka kemika lāʻau lapaʻau, kahi i hoʻohana ʻia ai i ka hoʻolālā ʻana i nā mea hoʻopaneʻe enzyme e pili ana i ka boronate a me nā ligand receptor.ʻO ka holoʻokoʻa, ʻo Boc-phenylboronic acid kahi reagent waiwai e kōkua i ka holomua i ka kemika synthetic a me ka noiʻi ʻike lāʻau.