![3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99% Kiʻi Hōʻikeʻike](http://cdn.globalso.com/xdbiochems/54827-17-71.jpg)
3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99%
| Helu Helu | XD90518 |
| inoa mea kūʻai | 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine |
| CAS | 54827-17-7 |
| ʻĀpana Molekala | C16H20N2 |
| Kaumaha Molecular | 240.34 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 29215990 |
Huahana Huahana
| Ka nana aku | Keʻokeʻo, keʻokeʻo keʻokeʻo a hina a melemele paha |
| Hoʻāʻo | >99% |
| Nalo ma ka maloo | <2.0% |
| No ka noiʻi wale nō, ʻaʻole no ke kanaka | noiʻi wale nō, ʻaʻole no ke kanaka |
ʻO Ricin toxin (RT) ka lua o nā mea make loa i ʻike ʻia;ua koho ʻia e ka CDC ma ke ʻano he mea koho.Hana ʻia ʻo RT e ka mea kanu castor bean;he 50,000 tons o RT i hana ʻia i kēlā me kēia makahiki ma ke ʻano he ʻaila ʻaila.Loaʻa iā RT ʻelua mau ʻāpana, he kaulahao ribotoxic A (RTA) a me ke kaulahao B binding galactose (RTB).Hoʻopili ʻo RT i nā cell mammalian āpau a i ka wā i hoʻokomo ʻia, hoʻokahi RTA catalytically hoʻopau i nā ribosomes āpau i loko o kahi keena.Hoʻohana ʻia ma ke ʻano he aerosol, ʻo RT ke kumu o ka pōʻino o ka māmā a me ka fibrosis a me ka make.ʻAʻohe lāʻau lapaʻau i ʻae ʻia e ka Food and Drug Administration a ʻo nā lāʻau lapaʻau e pono wale nō i nā hola mua ma hope o ka hoʻolaha ʻana.Ua hoʻomohala mākou i kahi kano kano RTA hou i loaʻa ʻelua mau hoʻololi V76M/Y80A (RiVax).Hōʻike ʻia ka protein i loko o Escherichia coli a he nontoxic a immunogenic i nā ʻiole, nā ʻiole, a me nā kānaka.Ke ho'āʻo ʻia nā ʻiole i hoʻopaʻa ʻia me nā ʻiole i hoʻopaʻa ʻia, aerosolized, a i ʻole i hāʻawi waha ʻia (gavaged) RT, palekana loa lākou.Ua hoʻomohala mākou i kahi ʻano ʻano thermostable, aluminika-adjuvant o RiVax a hoʻāʻo iā ia i loko o nā macaques rhesus.Ma hope o ʻekolu mau inikini, ua hoʻomohala nā holoholona i nā antibodies i pale pono iā lākou mai kahi make make o ka aerosolized RT.Ua hoʻokaʻawale kēia mau antibodies iā RT a hoʻokūkū i nā pae like ʻole me kahi papa o ka neutralizing a me ka nonneutralizing mouse monoclonal antibodies i ʻike ʻia e ʻike i nā epitopes kikoʻī ma ka RTA maoli.Hiki ke hōʻike ʻia ka hōʻike hoʻokūkū antibody i kahi hōʻailona immunologic o ka pale.ʻO ka mea nui, ua ʻike ʻia ka pūlima like me ka hoʻohana ʻana i ka sera mai nā kānaka i hoʻopaʻa ʻia e RiVax.
