Nā huahana

(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, i kapa ʻia ʻo BISO pūhui, he mea hoʻohui kemika me kahi hale kūʻokoʻa e hāʻawi iā ia iho i kekahi mau mea hoʻohana i ke kahua o ka lāʻau kemika a me ka hoʻomohala ʻana i ka lāʻau.ʻO ka loaʻa ʻana o ka benzo[d]isothiazol-3-yl moiety i loko o kona ʻano e hōʻike ana e pili ana paha ka BISO me nā ʻōnaehana neurotransmitter kikoʻī i loko o ka lolo, e like me nā ʻōnaehana glutamate a i ʻole GABAergic.Hoʻopili ʻia kēia mau ʻōnaehana neurotransmitter i nā maʻi neurological e like me ka epilepsy, ka hopohopo, a me nā maʻi ʻeha.Hiki i nā mea noiʻi ke ʻimi i ka mana o BISO e hoʻololi i kēia mau ʻōnaehana a hoʻomohala i nā mea lapaʻau hou no nā kūlana neurological. nā pahuhopu olaola.ʻO kona ʻano ʻekolu-dimensional a me ka hele ʻana o nā pūʻulu hana hiki ke launa pū me nā mea loaʻa kūikawā a i ʻole nā ​​enzymes, e ʻae ai i ka hoʻolālā ʻana o nā lāʻau lapaʻau koho a ikaika.Hiki i nā mea noiʻi ke hoʻohana i kēia kumu hoʻolālā e hoʻomohala i nā molekala liʻiliʻi e kuhikuhi ana i nā mea hoʻokipa e pili ana i nā maʻi like ʻole, e like me ke kanesa, nā maʻi cardiovascular, a i ʻole nā ​​maʻi maʻi.ʻO ka loaʻa ʻana o kahi pūʻulu i hoʻopiʻi ʻia e hiki ai ke hoʻokumu ʻia nā paʻakikī ionic me nā molekole i hoʻopiʻi maikaʻi ʻia, e like me nā nucleic acids a i ʻole nā ​​protein.Hiki i kēia mau mea paʻakikī ke hoʻoikaika i ka hāʻawi ʻia ʻana o nā molekole bioactive i loko o nā cell a i ʻole nā ​​kiko kikoʻī, e hoʻonui ana i ka hopena therapeutic ʻoiai e hōʻemi ana i nā hopena ʻaoʻao systemic.Hāʻawi kona ʻano kūʻokoʻa i nā manawa no nā mea lapaʻau lapaʻau e ʻimi i kāna mau waiwai pharmacological a hoʻopaʻa i kona hiki ke loaʻa i ka lāʻau lapaʻau.Pono nā mea noiʻi e makaʻala i ka wā o kāna synthesis, lawelawe ʻana, a me ka mālama ʻana e hōʻoia i ka palekana a hōʻemi i nā pilikia. ]-2-ium4-methylbenzenesulfonate, a i ʻole BISO, paʻa i ka ʻōlelo hoʻohiki no nā noi like ʻole i ka lāʻau kemika a me ka hoʻomohala lāʻau.Hāʻawi kona ʻano kūʻokoʻa i nā manawa no ka loaʻa ʻana o nā mea lapaʻau hou, nā ʻōnaehana lawe lāʻau i manaʻo ʻia, a me ka modulation o nā ʻōnaehana neurotransmitter.Eia nō naʻe, pono ka noiʻi nui e wehewehe piha i kona hiki a hoʻopaʻa pono i kāna hoʻohana ʻana i ka lāʻau lapaʻau.