Nā huahana

ʻO 4-(4-Fluorophenyl) -6-isopropyl-2- [(N-methyl-N-methylsulfonyl) amino] pyrimidine-5-yl-methanol, i ʻike ʻia ʻo Z6, he mea hoʻohui kemika me nā mea hiki ke hoʻohana ʻia i ka lāʻau lapaʻau. .ʻO kona hoʻolālā kūikawā a me nā hui hana e lilo ia i moho hoihoi no ka ʻike ʻana a me ka hoʻomohala ʻana i ka lāʻau.He kuleana ko ka mumū i loko o nā maʻi he nui, e like me ka rheumatoid arthritis, ka maʻi ʻāʻī a me ka hānō.ʻO Z6 ka fluoro-substituted phenyl group a me ka pyrimidine core e kūpono ia no ka launa pū ʻana me nā pahuhopu kikoʻī i komo i loko o ke kaʻina hana inflammatory, hiki ke alakaʻi i ka hoʻomohala ʻana i nā lāʻau anti-inflammatory hou.ʻO nā maʻi maʻi maʻi he mea koʻikoʻi koʻikoʻi no ke olakino olakino, a he pono mau no nā lāʻau antiviral hou a maikaʻi.ʻO ka hiki ʻana o ka hui isopropyl ma Z6 e hoʻonui i kāna mau waiwai hydrophobic, e ʻae iā ia e komo i nā membrane viral a keʻakeʻa i ka replication viral.Hiki ke hoʻonui ʻia kona mau hiʻohiʻona e hoʻopaʻa pono i nā enzyme viral a i ʻole nā ​​protein, e alakaʻi ana i ka hoʻomohala ʻana i nā lāʻau antiviral potent.Loaʻa pinepine ka hui phenyl a me ka pyrimidine core i loko o nā pūhui me ka hana anticancer.Ma ka hoʻololi ʻana i ka hoʻolālā Z6, hiki ke hana i nā derivatives e koho koho i nā cell cancer, ke kāohi ʻana i ko lākou ulu ʻana a me ka hoʻoulu ʻana i ka apoptosis ʻoiai e mālama ana i nā cell olakino.Hiki ke hoʻonui ʻia ka hoʻoheheʻe ʻana a me ka paʻa o ka pūhui e hoʻomaikaʻi i kona pono a hōʻemi i nā hopena ʻaoʻao.Hāʻawi ia i ka maʻalahi no ka hoʻololi ʻana a me ka hoʻomaikaʻi ʻana, e ʻae ana i ka ʻimi ʻana i nā pilina hana-hana a me ka ʻike ʻana i nā pūhui alakaʻi no ka hoʻomohala hou ʻana.ʻO kāna mau hiʻohiʻona a me nā hui hana e kūpono ia no nā kumu therapeutic like ʻole, me nā noi anti-inflammatory, antiviral, a me anticancer.Me ka noiʻi hou a me ka hoʻomohala ʻana, paʻa ʻo Z6 a me kāna mau derivatives i ka hiki ke hana i nā haʻawina nui i ka ʻike ʻana i ka lāʻau lapaʻau a kōkua i ka hoʻomohala ʻana i nā moʻolelo a me nā lāʻau lapaʻau maikaʻi.