Nā huahana

ʻO T-Butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate he hui kemika me kahi ʻano paʻakikī i hoʻohana mau ʻia i ka synthesis organik a ma ke ʻano he hui pale i ka kemika carbohydrate.Ua ʻike ʻia no kona hiki ke pale pono i nā pūʻulu hydroxyl a pale i nā hopena i makemake ʻole ʻia i ka wā o nā hoʻololi kemika. ʻO ka dihydroxyhexanoate i loko o ka synthesis o nā pūhui organik paʻakikī.ʻO nā pūʻulu hydroxyl he mea hoʻoikaika nui a hiki ke hana i nā hopena ʻaoʻao makemake ʻole i ka wā o ka hoʻololi kemika.Ma ka pale koho ʻana i kēia mau pūʻulu me ka T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, hiki i nā chemists ke hoʻomalu i nā hopena a loaʻa nā huahana i makemake ʻia.Ma hope o ka pau ʻana o nā hoʻololi kemika i makemake ʻia, hiki ke wehe maʻalahi ka hui pale, e ʻae ai i ka hoʻihoʻi ʻana o nā hui hydroxyl kumu. Hoʻohana pinepine ʻia ka 3,5-dihydroxyhexanoate no ka pale ʻana i nā molekole kō.Loaʻa i nā kō i nā pūʻulu hydroxyl he nui e hiki ke hana me nā reagents, e alakaʻi ana i nā huahana i makemake ʻole ʻia.Ma ka pale ʻana i kēia mau pūʻulu hydroxyl me T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, hiki i nā mea kemika ke hoʻoponopono i nā pūʻulu hydroxyl i koe me ka ʻole o ke keakea ʻana.ʻAe kēia i ka synthesis o nā derivatives kōpaʻa paʻakikī a me ke aʻo ʻana i ka launa pū ʻana o ka carbohydrate-protein a i ʻole ka synthesis o glycoconjugates. Hoʻohana pinepine ʻia ka hui pale dihydroxyhexanoate i ka wā o ka synthesis o nā huahana kūlohelohe, lāʻau lapaʻau, a me nā mea hoʻohui biologically active.ʻO kona palekana a me nā waiwai deprotection e hiki ai i nā chemists ke komo i kahi ākea o nā molekala like ʻole.ʻO ka pale ʻana o nā pūʻulu hydroxyl kikoʻī e kōkua i ka hoʻomalu ʻana i nā ala hopena a hoʻokō i ka regioselectivity a i ʻole stereoselectivity i makemake ʻia. hoʻohana nui ʻia i loko o ka kemika synthetic organic, ʻoi aku ka nui o ka pale a me ka hoʻopau ʻana i nā pūʻulu hydroxyl.ʻO kāna hana kūikawā e hiki ai i ka pale koho, hiki i nā chemists ke kāohi i nā hopena a loaʻa nā huahana i makemake ʻia.Hoʻopili ʻia kāna mau noi mai ka synthesis o nā pūhui organik paʻakikī i ka kemika carbohydrate a me ka hana ʻana i nā huahana kūlohelohe a me nā lāʻau lapaʻau.ʻO ka hiki o ka pūhui ke pale aku i nā pūʻulu hydroxyl me ka maikaʻi e lilo ia i mea waiwai nui i nā ʻano like ʻole o ka noiʻi kemika a me ka hoʻomohala ʻana.