Hāʻawi ʻia nā ʻiole i hoʻokahi pānaʻi o ka mea kanu kumu phenolic antioxidant Quercetin (QC) i ka manuahi, liposome encapsulated a me galactosylated liposome encapsulated forms 2 h ma mua o ka hepatotoxic dose o carbontetrachloride (CCl4, 40% v/v i ka ʻaila ʻoliva, 1 ml/kg b .wt).Ma waena o kēlā mau ʻano ʻano QC like ʻole ʻekolu i hoʻāʻo ʻia, ʻo QC liposomal galactosylated wale nō i hāʻawi i ka pale nui mai CCl4 i hoʻokomo ʻia i ka pōʻino o ka hepatic oxidative.Ma hope o 24 mau hola o ka injection (SC) ʻike ʻia nā cell hepatic o nā ʻiole hiki ke loaʻa i ka CCl4 i hoʻokomo ʻia i ka pōʻino oxidative a ua nānā ʻia e ka nui o ka conjugated diene i loko o ka membrane hepatic.ʻO ka piʻi ʻelua o ka conjugated diene e ka induction o CCl4 ua hoʻemi ʻia a hiki i ka pae maʻamau e ka galactosylated liposomal QC pre-treatment.ʻO ka carbontetrachloride i hoʻokomo i ka pōʻino membrane i loko o nā pūnaewele hepatic a ua hoʻoholo ʻia e ka serum pathological a me ka nānā ʻana i ka histopathological histopathological serum koko.Ua loiloi hou ʻia ka pōʻino o ka membrane e ka hoʻokomo ʻana o CCl4 e ka emi ʻana o ka pae o ka membrane plasma (PM) i hoʻopaʻa ʻia i ka enzyme Na+/K+ ATPase hana a ua hoʻonui ʻia e ka hana mua o ka galactosylated liposomal QC.ʻO ka carbontetrachloride i hoʻoulu i ka emi nui o ka enzymatic a me ka molecular endogenous antioxidant pae i loko o nā cell hepatic. ʻO ke kaumaha i loko o ka ʻōnaehana antioxidant i loko o nā pūnaewele hepatic ua pale loa ʻia e kahi pā hoʻokahi o ka galactosylated lipsosomal QC ma mua o ka mālama ʻana iā CCl4.Ua manaʻo ʻia ka lawe ʻana o ke akepaʻa o QC ma hope o 2 mau hola o ka hoʻoheheʻe flavonoid (8.9 micromol/kg kino kaumaha) (free a liposomal forms) a ʻo 85% o ka injected QC i loaʻa i loko o ke ake i ka hihia o ka galactosylated liposomal QC.ʻOiai ʻo 25% wale nō o ka mea i hoʻopaʻa ʻia i ʻike ʻia i loko o ke ake i ka wā i hoʻokomo ʻia ai ka nui like o ka QC manuahi.Hoʻokomo pū ʻo Carbontetrachloride i ka hoʻololi ʻana i ka fluidity membrane a ua loiloi ʻia e ka emi ʻana o ka micro-viscosity membrane.ʻO ka hoʻomaʻamaʻa mua ʻana o QC manuahi ka hopena ʻaʻohe pale i ka CCl4 i hoʻoulu ʻia i ka piʻi ʻana o ka wai o ka membrane hepatic, akā ʻo ka galactosylated liposomal QC i hoʻoikaika nui i ka hoʻonui ʻana.Ua hōʻike ʻia nā hopena o kēia haʻawina ʻo QC i loko o ka liposome galactosylated hiki ke hana i kahi pale koʻikoʻi e kūʻē i ka hōʻeha hepatocellular i hoʻoiho ʻia e CCl4.
