Nā huahana

ʻO nā haʻahaʻa submillimolar o nā cytotoxic bile acids (BAs) e hoʻoulu i ka make cell ma o apoptosis.Ma ka ʻaoʻao ʻē aʻe, ua hōʻike ʻia kekahi mau cytoprotective BA e pale i ka apoptosis i ka pae hoʻohālikelike like.Eia nō naʻe, ʻaʻole maopopo nā ʻano hana a BA e hoʻomaka ai i kēia mau hopena hōʻailona.Ua manaʻo ʻia kēia noiʻi e hoʻoholo inā hiki i ka cytotoxic a me ka cytoprotective BAs, i ka physiologically active concentrations, ke hoʻololi i nā waiwai biophysical o nā membrane lipid, hiki ke unuhi i nā loli i ka paepae apoptotic o nā cell.ʻIke ʻia ka paʻa ʻana o nā BA i nā membrane ma o ka hoʻololi ʻana o nā ʻāpana fluorescence o nā BA derivatized kūpono.Hoʻokaʻawale ʻia kēia mau derivatives me ka pilina kiʻekiʻe i ka wai maʻi ma mua o ka cholesterol-enriched wai i kauoha ʻia.Ua hōʻike pū ʻia nā BA ʻaʻole i hōʻailona ʻia he wahi papa ma luna o ka launa pū ʻana me ka membrane lipid.Hoʻohui ʻia, ʻo ka hoʻopili ʻana o nā cytotoxic BA me nā membrane i hopena i ka hoʻonui ʻana o ka membrane, e like me ka hoʻopili ʻana mai ka ʻike FRET.Eia kekahi, ua hōʻike ʻia ua hiki i nā cytotoxic BAs ke hoʻopau nui i ke kauoha ʻana o ka membrane e ka cholesterol ma nā physiologically active concentrations o ka BA, kahi hopena i pili ʻole me ka wehe ʻana i ka cholesterol.Ma ka ʻaoʻao ʻē aʻe, ʻaʻohe hopena o ka cytoprotective bile acid i nā waiwai membrane.Ua hoʻoholo ʻia, hāʻawi ʻia i nā hopena i ʻike ʻia ma ka rigidity membrane, hiki ke hoʻopili ʻia ka hana apoptotic o cytotoxic BAs me nā hoʻololi i ka hui membrane plasma (e like me ka modulation o nā domain lipid) a i ʻole me ka hoʻonui ʻana i ka pili o ka membrane mitochondrial no nā protein apoptotic.