Nā huahana

ʻO ka 4-Hydroxyphenylboronic acid pinacol ester, i kapa ʻia ʻo HBP ester, he mea hoʻohui kemika e ʻike i nā noi ma nā ʻano āpau ma muli o kāna mau waiwai kūʻokoʻa e like me ka ester boronic.ʻO kona ʻano kemika he ʻātoma boron i hoʻopili ʻia i kahi pūʻulu phenolic ma o ka loulou ester, e lilo ana ia i poloka hale waiwai no ka synthesis organik. -ka hoʻohui ʻana.Hoʻopili kēia hopena i ka hoʻokumu ʻana i kahi paʻa kalapona-carbon ma waena o kahi aryl a vinyl boronic acid a me kahi aryl a vinyl halide a triflate paha.Ma ke ʻano he ester boronic, hana ka HBP ester ma ke ʻano he precursor i ka waika boronic e pili ana, hiki ke hana i ka hopena hoʻohui keʻa me nā electrophiles like ʻole, e alakaʻi ana i ka hoʻokumu ʻana i nā molekala organik paʻakikī.He mau noi koʻikoʻi kēia hopena i ka lāʻau kemika, agrochemical synthesis, ʻepekema waiwai, a me nā wahi ʻē aʻe he nui o ka synthesis organik. mole mole.No ka laʻana, hiki ke pale ʻia ka pūʻulu hydroxyl o ka phenolic moiety a ma hope e hoʻoneʻe ʻia, e ʻae i ka hoʻololi koho a me ka hoʻololi ʻana o ka pūhui.Hoʻohana kēia waiwai i ka HBP ester i mea waiwai nui i ka synthesis o nā lāʻau lapaʻau, agrochemical, a me nā kemika maikaʻi ʻē aʻe.Ma muli o ka ʻātoma boron i loko o kona ʻano, hiki iā ia ke hana i nā paʻakikī hiki ke hoʻohuli ʻia me nā diols a i ʻole polyols, e like me nā sugars a i ʻole nā ​​​​waihā.Hiki i kēia waiwai ke hoʻomohala i nā mea ʻike ma muli o ka boronate no ka ʻike ʻana i ka glucose, a me nā molekole pili olaola ʻē aʻe.Hiki ke hoʻohui ʻia ka HBP ester i loko o nā paepae ʻike like ʻole, me ka fluorescent a i ʻole colorimetric probes, e hāʻawi ana i kahi ala e ʻike ai i nā analytes kikoʻī i loko o nā mea olaola a i ʻole kaiapuni. no kona kuleana kūpono i nā ʻōnaehana lawe lāʻau.Hiki i ka boron ke komo i nā pilina me nā biomolecules, e like me ka nucleic acids a i ʻole nā ​​proteins, a ua ʻimi ʻia no ka hāʻawi ʻana i ka lāʻau lapaʻau i manaʻo ʻia, hoʻonui ʻia ka lawe ʻana i ke kelepona, a i ʻole ka hoʻokuʻu ʻia ʻana o nā mea lapaʻau. hoʻohana ʻia i ka synthesis organik, nā noi sensing, a me nā ʻōnaehana lawe lāʻau.ʻO kāna hana boronic ester hiki iā ia ke komo i ka hopena o Suzuki-Miyaura cross-coupling a hoʻololi i nā hui hana, e hoʻonui ana i kāna pono synthetic.Hoʻohui, hiki i ka HBP ester ke hana i nā paʻakikī hiki ke hoʻohuli ʻia me nā diols, e lilo ia i mea waiwai no ka hoʻomohala ʻana i nā mea ʻike molekala.ʻO kona hiki i nā ʻōnaehana hoʻopuka lāʻau e hōʻike hou aku i kona koʻikoʻi ma ke ʻano he hui nui i nā ʻano ʻepekema a me ka ʻenehana.