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(4R-Cis)-1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol -1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate kahi hui me kahi hoʻolālā kemika paʻakikī.ʻOiai hiki ke kaupalena ʻia ka ʻike kikoʻī e pili ana i ka hoʻohana ʻana o kēia pūhui, hiki iā mākou ke kūkākūkā i kāna mau noi kūpono e pili ana i kona mau hiʻohiʻona a me nā ʻano maʻamau o nā pūhui like. ma ke ʻano he mea hoʻoheheʻe.He mea hoʻoheheʻe maʻamau ʻo Dioxane, ʻo ia hoʻi i loko o ka kemika organik, no ka mea, hiki ke hoʻoheheʻe ʻia i ka wai a hiki ke hoʻoheheʻe maikaʻi ʻia no ka nui o nā molekala organik.ʻO ka loaʻa ʻana o kahi moiety dioxane i loko o kēia pūhui e hōʻike ana e loaʻa iā ia nā waiwai solubility like.Hiki i ka hoʻololi ʻana o ka fluorine i loko o nā pūhui organik ke hoʻonui i kā lākou waiwai pharmacokinetic, hiki ke hoʻonui i ko lākou mana a i ʻole bioavailability.ʻO ka loaʻa ʻana o kahi hui carbonyl phenylamino hiki ke hōʻike i ka hiki ke launa pū me nā pahuhopu olaola, hiki paha ke alakaʻi i nā hopena therapeutic.Hiki ke ʻimi ʻia ma ke ʻano he hui alakaʻi no ka hoʻomohala ʻana i nā lāʻau lapaʻau hou e kuhikuhi ana i nā maʻi kūikawā.Eia naʻe, he mea nui e hoʻomaopopo he pono nā noiʻi hou aku e hoʻoholo i kāna mau waiwai pharmacological maoli, me kona pono, ka hana o ka hana, a me nā hopena ʻaoʻao. a i ʻole ma ke ʻano he ʻāpana i ka synthesis kemika.Ua noiʻi ʻia nā derivatives Nitronyl a me pyrrole no ko lākou hoʻohana ʻana ma ke ʻano he mea hoʻokele organik, catalysts, a i ʻole nā ​​​​papa kūkulu hale no nā hale paʻakikī.Eia naʻe, pono kēia mau noi i ka noiʻi hou a me ka hoʻonui ʻana i nā ʻano synthesis. ʻO ke ʻano holoʻokoʻa, ka pūhui (4R-Cis) -1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl) -5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate e hōʻike ana i ka hiki ke hoʻohana i ka lāʻau lapaʻau. ʻepekema mea waiwai, a i ʻole synthesis kemika.Eia nō naʻe, he mea koʻikoʻi ka hana noiʻi nui e loiloi i kāna mau waiwai, hoʻomohala i nā ala synthesis kūpono, a hoʻoholo i kāna mau noi kikoʻī i kēlā me kēia kahua.