Nā huahana

He ʻumikūmālima platinum (II)-metalalointercalators i hana ʻia e hoʻohana i nā ligands 1,10-phenanthroline (phen) i pani ʻia, me 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) a me dipyrido [3,2-d : 2',3'-f] quinoxaline (dpq), a me achiral ethylenediamine (en) a me na ligands ancillary chiral 1S,2S-diaminocyclohexane (S,S-dach) a me 1R,2R-diaminocyclohexane (R,R-dach) .Ua hoʻoholo ʻia ko lākou cytotoxicity i ka L1210 murine leukemia cell line me ka hoʻohana ʻana i nā assays inhibition ulu.ʻO nā mea paʻakikī metala cytotoxic ka mea i loaʻa nā ligands ancillary S, S-dach a me nā ligands intercalating 5-CH3-phen.Hoʻokahi metallointercalator [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), hōʻike i ka piʻi ʻana o 5-10-fold i ka cytotoxicity i hoʻohālikelike ʻia me ka cisplatin agent clinical.Mai nā hoʻokolohua hoʻopaʻa ʻana i ka DNA, ʻaʻohe ʻokoʻa koʻikoʻi ma waena o kekahi o nā mea metala, e hōʻike ana ʻaʻole ʻo ka pilina paʻa DNA a ʻaʻole hoʻi ke ʻano o ka hoʻopaʻa ʻana/DNA addduct i hoʻokumu ʻia ʻo ia wale nō ka mea e hoʻoholo ai i ka cytotoxicity o kēia ʻohana platinum (II) -based. metallointercalators.