Nā huahana

Hoʻomaka ka hoʻokumu ʻana o Acyl-CoA i ka metabolism momona momona.Hoʻokumu ʻia nā Acyl-CoAs e ka ligation o kahi waikawa momona i Coenzyme A i hoʻopili ʻia e kahi ʻohana nui o acyl-CoA synthetases (ACS).ʻO ka mea ʻē aʻe, hiki ke hoʻokahe ʻia nā acyl-CoA e kahi ʻohana acyl-CoA thioesterases (ACOT).Ma ʻaneʻi, ua hoʻoholo mākou i ka hoʻoponopono transcriptional o nā enzyme ACS a me ACOT ma waena o nā ʻiʻo a me ka pane ʻana i nā perturbations metabolic.ʻIke mākou i nā hiʻohiʻona o ka hoʻoponopono i hoʻonohonoho ʻia i loko a ma waena o kēia mau ʻohana gene a me nā hoʻoponopono kūʻokoʻa e kū nei ma ke ʻano pili i ke kino a me ke ʻano physiologically.Ma muli o nā loli i ʻike ʻia i ka mRNA ACOT kaulahao lōʻihi a me ka nui o ka protein i loko o ke ake a me ka ʻiʻo adipose, ua hoʻoholo mākou i ka hopena o ka hoʻonui ʻana i ka hana cytosolic long-chain thioesterase i ka metabolism o ka momona i loko o kēia mau kiko ma o ka hana ʻana i nā ʻiole transgenic e hōʻike nui ana i kahi mutant hyperactive o Acot7 i ka ke akepaʻa a i ʻole ka ʻiʻo adipose.ʻAʻole hiki i ka hana pālua ʻana o ka cytosolic acyl-CoA thioesterase i ka pale ʻana i ka mic e mai ka momona i hoʻokomo ʻia i ka meaʻai, ka momona a i ʻole ka insulin resistance, akā naʻe, ʻo ka overexpression o Acot7 i loko o nā adipocytes i hoʻolilo i ka ʻiole i ke anuanu.Hoʻohui pū ʻia kēia mau ʻikepili i nā ʻano hoʻoponopono ʻokoʻa o nā enzymes ACS a me ACOT a ke hana nei kēia mau enzymes i kahi ʻano i hoʻonohonoho ʻia e hoʻomalu i ka metabolism o ka momona momona ma ke ʻano pili i ke kino.