Nā huahana

ʻEkolu pūʻulu o nā monkey cynomolgus kāne makua (Macaca fascicularis) i hōʻike ʻia i ka 200 micrograms/m3 ammonium hexachloroplatinate [(NH4)2PtCl6], 200 micrograms (NH4)2PtCl6 i ka manawa like me 1 ppm ozone (O3), a i ʻole 1 ppm ozone (O3) wale nō.Ua hōʻike ʻia nā holoholona ma ka inhalation no 6 mau hola i ka lā, 5 mau lā o ka pule no 12 wk.ʻO ka hoʻolālā hoʻokolohua ʻo ia ka methacholine preexposure a me Na2PtCl6 bronchoprovocation ho'āʻo loiloi, Na2PtCl6 paepae ʻili hoʻāʻo, a me ka sera no ka loiloi o nā antibodies.ʻElua pule ma hope o ka hōʻike ʻana i ka 12-wk, ua loiloi hou ʻia kēia mau helu like.ʻAʻole i hoʻopilikia nui ʻia ka hana pulmonary baseline e nā regimens exposure;akā naʻe,ʻo ka hui pūʻana o kaʻikeʻana i ka O3 a me (NH4) 2PtCl6 i hoʻemi nui i ka paʻakai platinum (Pt) a me ka methacholine e pono ai e hoʻonui i ka awelika o ka pulmonary flow resistance (RL) 200% (EC200 RL).ʻAʻohe hopena koʻikoʻi o ka Ozone a i ʻole Pt i kēia mau ʻāpana.ʻO ka Platinum a me ka methacholine EC200 RL waiwai i hoʻopili nui ʻia no nā pūʻulu Pt ʻelua ma hope o ka hoʻolaha ʻana.Ua hōʻike ʻia kēia mau ʻikepili i hoʻonui pinepine ʻia ka hoʻolaha ʻana o O3 a me Pt ​​i nā kikoʻī kikoʻī (Pt) a me ka nonspecific (methacholine) bronchial hyperreactivity ma mua o ka ʻike ʻana iā O3 a i ʻole ka paʻakai Pt wale nō.ʻO ka hui pū ʻana o O3 a me Pt ​​e hoʻonui nui i ka ulu ʻana o nā hoʻāʻo ʻili Pt maikaʻi ke hoʻohālikelike ʻia me nā hui ʻike ʻē aʻe.E like me ka ʻike kanaka, radioallergosorbent testing (RAST) no Pt-specific antibodies ʻaʻole i maʻalahi e like me ka hoʻāʻo ʻana i ka ʻili pololei i ka ʻike ʻana i ka poʻe maʻi.