Nā huahana

Ua hoʻokumu ʻia nā papa polimer poli ma muli o nā copolymers poloka o ka poly(oligo(ethylene glycol) methacrylate) (POEGMA) a me ka poly(glycidyl methacrylate) (PGMA) i hoʻokumu ʻia ma nā wafer silika e nā mea hoʻoikaika i hana ʻia e ka electron transfer atom transfer radical polymerization (AGET ATRP).Hiki ke hoʻohui ʻia nā ʻano biomolecule ʻokoʻa i kēia mau ʻāpana polaki ma ka pane ʻana o nā pūʻulu epoxide PGMA me nā pūʻulu amino i loko o ka biomolecule, ʻoiai ʻo POEGMA, ka mea e kūʻē i ka adsorption protein nonspecific, hāʻawi i kahi kaiapuni antifouling.Hōʻike ʻia nā ʻili e ka kihi pili wai, ellipsometry, a me Fourier transform infrared spectroscopy (FTIR) e hōʻoia i nā hopena hoʻololi.Ua ʻike ʻia ka hoʻokaʻawale ʻana o nā poloka copolymer i nā papa e AFM.Ua noiʻi ʻia ka hopena o nā waiwai o ka ʻili i ka conjugation protein me ka hoʻohana ʻana i nā ʻano radiolabeling.Ua hōʻike ʻia ʻo nā ʻili me nā papa POEGMA ua kūpaʻa i ka protein, aʻo ka nui o ka protein i hoʻohui ʻia i ka diblock copolymer i hoʻololi ʻia i hoʻonui ʻia me ka hoʻonui ʻana i ka mānoanoa papa PGMA.Hiki ke hoʻomalu ʻia ka hana o ka lysozyme conjugated ma ka ʻili ma ka hoʻololi ʻana i ka mānoanoa o ka papa copolymer.I ka hoʻohui ʻia ʻana o ka biotin i nā grafts copolymer block, ua kūpaʻa ka ʻili i ka adsorption protein nonspecific akā ua hōʻike ʻia ka paʻa ʻana o ka avidin.Hiki ke hoʻohana ʻia kēia mau waiwai, ʻo ia hoʻi, ka nui a me ka hana o nā biomolecules conjugated a me ka kikoʻī o ka pilina me nā biomolecules i hoʻopaʻa ʻia no ka hoʻomaikaʻi ʻana i ka ratio hōʻailona-a-noise i nā noi sensor.ʻO ka mea maʻamau, hiki ke hoʻohana ʻia ia mau ʻili e like me nā mea ʻike olaola o ka kikoʻī kiʻekiʻe no nā biomaterial hana.