Nā huahana

Hoʻemi ʻia ka maikaʻi o nā molekele antibiotic i ka mālama ʻana i ka maʻi pneumonia Pseudomonas aeruginosa ma muli o ka hoʻolaha ʻana o ke kū'ē bacteria.ʻO ka noho ʻana o nā ʻōnaehana kamaʻilio bacteria, e like me ka quorum sensing, ua hāʻawi i nā manawa hou no ka mālama ʻana.Hoʻopau maikaʻi nā Lactonases i ka acyl-homoserine lactone-based bacterial quorum sensing, me ka hoʻopili ʻana i kēia mau enzymes he mau lāʻau anti-Pseudomonas hou hiki ke loiloi ʻia i ka pneumonia. ka make ʻana o ka ʻiole P. aeruginosa pneumonia. No ka loiloi ʻana i ka hoʻopiʻi ʻana o SsoPox-I-mediated quorum quenching, ua ana mua mākou i ka hana o ka virulence gene lasB, ka synthesis o pyocianin, ka hana proteolytic o ka hoʻokuʻu ʻana i ka bacteria a me ka hoʻokumu ʻana o ka biofilm o kahi. Hoʻoulu ʻia ke kumu PAO1 i mua o ka lactonase.I loko o kahi ʻano hoʻomake nui o P. aeruginosa pneumonia i nā ʻiole, ua loiloi mākou i nā hopena o kahi lapaʻau intra-tracheal mua a hoʻopaneʻe paha me SsoPox-I i ka make, helu maʻi bacteria a me ka pōʻino o ka māmā. Ua hoʻemi ʻo SsoPox-I i ka hana gene virulence PAO1 , pyocianin synthesis, hana proteolytic a me ka hana biofilm.ʻO ka hoʻohana mua ʻana o SsoPox-I i hōʻemi i ka make o nā ʻiole me ka maʻi maʻi maʻi mai 75% a i 20%.Ua hōʻemi nui ʻia ka pōʻino o ka maʻi maʻi maʻi akā ʻaʻole i hoʻololi ʻia ka helu o ka maʻi bacteria e ka lāʻau lapaʻau.Hoʻopili ʻia kahi lāʻau lohi me ka hōʻemi nui ʻole o ka make. Hōʻike kēia mau hopena i nā hopena pale o ka lactonase SsoPox-I i P. aeruginosa pneumonia a wehe i ke ala no ka hoʻohana therapeutic e hiki mai ana.