Nā huahana

ʻO NADPH oxidases kahi ʻohana o nā enzyme e hoʻohua ai i nā ʻano oxygen reactive (ROS).ʻO ka NOX1 (NADPH oxidase 1) a me NOX2 oxidases nā kumu nui o ROS i ka paia o ke aʻa i nā kūlana e like me ke hypertension, hypercholesterolaemia, diabetes a me ka ʻelemakule, a no laila he mea nui lākou i ke koʻikoʻi o ka oxidative, endothelial dysfunction a me ka mumū vascular i lalo. ka hoʻoponopono hou ʻana o ke aʻa a me ka atherogenesis.Ma kēia Hōʻike, hoʻomaka mākou i ka manaʻo i hoʻohālikelike ʻia i ka hoʻohana ʻana i nā antioxidants maʻamau, ka pale ʻana i ka NOX1 a me ka NOX2 oxidases kahi ala maikaʻi loa no ka hakakā ʻana i ke kaumaha oxidative.Hōʻike pōkole mākou i kekahi mau mea hoʻopiʻi NADPH oxidase maʻamau a puka mai.Eia kekahi, ke hōʻike nei mākou i ka hana koʻikoʻi o ka NADPH oxidase regulatory subunit, p47phox, i ka hana o nā vascular NOX1 a me NOX2 oxidases, a manaʻo pehea e hiki ai i ka ʻike maikaʻi ʻana o kāna mau pilina molekala kūikawā ke hiki i ka hoʻomohala ʻana i nā lāʻau lapaʻau isoform-selective novel e pale ai. a i ʻole mālama i nā maʻi maʻi cardiova scular.