Nā huahana

ʻO ka ʻeha o ke akepaʻa ma muli o ka lāʻau, ʻo ia kekahi o nā kumu nui o ka pau ʻana o ka lāʻau.He mea koʻikoʻi ka hiki ke wānana i ka hopena o ka ate o nā moho lāʻau mai kā lākou mau hana kemika e kōkua i ke alakaʻi ʻana i nā papahana ʻike lāʻau hoʻokolohua i nā lāʻau lapaʻau palekana.I loko o kēia noiʻi ʻana, ua hōʻuluʻulu mākou i kahi pūʻulu ʻikepili o nā pūhui 951 i hōʻike ʻia e hana i ka nui o nā hopena i loko o ke ake i nā ʻano ʻano like ʻole, ʻo ia hoʻi nā kānaka, nā rodents, a me nā nonrodents.Ua loaʻa nā hopena o ke akepaʻa no kēia pūʻulu ʻikepili ma ke ʻano he metadata assertional, i hana ʻia mai nā abstracts MEDLINE me ka hoʻohana ʻana i kahi hui kūʻokoʻa o nā ʻano lexical a me ka linguistic a me nā lula ontological.Ua kālailai mākou i kēia ʻikepili me ka hoʻohana ʻana i nā cheminformatics maʻamau a pane i nā nīnau e pili ana i ka concordance cross-species o nā hopena o ke ake, nā mea hoʻoholo kemika o nā hopena ate i loko o ke kanaka, a me ka wānana o ka mea i hāʻawi ʻia ke kumu i ka hopena ate i ke kanaka.Ua ʻike mākou he haʻahaʻa haʻahaʻa ka concordance o nā hopena ate (ca. 39-44%) ma waena o nā ʻano ʻano like ʻole, e hoʻonui ana i ka hiki ke hilinaʻi ʻia nā ʻano kikoʻī i nā hiʻohiʻona kikoʻī o ka hoʻolālā kemika.Hoʻopili ʻia nā pūhui e ko lākou ʻano like kemika, a ua nānā ʻia nā pūhui like ʻole no ka mea i manaʻo ʻia e like me kā lākou mau ʻano pili pili i ka ate.I ka hapanui o nā hihia, ua ʻike ʻia nā ʻano like ʻole no nā lālā o ka puʻupuʻu hoʻokahi, akā ʻike ʻia kekahi mau pūhui ma ke ʻano he outliers.ʻO nā mea i waho ke kumuhana o ka hoʻolaʻa hou ʻana mai ka MEDLINE a me nā kumu ʻikepili ʻē aʻe.I kekahi mau hihia, ua ʻike ʻia nā manaʻo koʻikoʻi hou aʻe, i kulike me nā mea i manaʻo ʻia e pili ana i nā mea like kemika.Ua hoʻololi hou ʻia nā ʻōlelo i nā annotation binary o nā kemika i lalo (ʻo ia hoʻi, ka hopena o ka ate vs ʻaʻohe hopena o ka ate), a ua hana ʻia nā kumu hoʻohālike binary quantitative structure-activity relationship (QSAR) e wānana inā e manaʻo ʻia kahi pūhui e hana i nā hopena ate i loko o ke kanaka.ʻOiai ke ʻano o ka heterogeneity o ka ʻikepili, ua hōʻike nā kumu hoʻohālike i ka mana wānana maikaʻi i loiloi ʻia e nā kaʻina hana cross-validation waho 5-fold.Ua hōʻoia hou ʻia ka mana wanana waho o nā kumu hoʻohālike binary QSAR e kā lākou noi ʻana i nā pūhui i kiʻi ʻia a aʻo ʻia paha ma hope o ke kūkulu ʻia ʻana o ke kumu hoʻohālike.I ka maikaʻi o kā mākou ʻike, ʻo kēia ka noiʻi mua no ka wānana toxic chemical i hoʻohana i ka hoʻohālike QSAR a me nā ʻenehana cheminformatics ʻē aʻe i ka ʻikepili nānā i hana ʻia e ke ʻano o ka mining text automated me ka curation manual liʻiliʻi, e wehe ana i nā manawa hou no ka hana ʻana a me ka hoʻohālike ʻana i ka toxicology chemical. ʻikepili.