Nā huahana

Ua manaʻo ʻia ka ʻeha o ke ea a me ka hoʻoponopono hou ʻana, me ka fibrosis, i mea kōkua nui i ka pathophysiology hānō.ʻO nā haʻawina mua o ka fibrosis ea ua hana nui ʻia i nā maʻi asthmatics haʻahaʻa a haʻahaʻa ma ka pae subepithelial "basement membrane" (SBM).ʻO ka haʻawina o kēia manawa ua hoʻolālā ʻia e loiloi i ka mānoanoa nui o ka ea SBM a me ka waiho ʻana o ka collagen submucosal, e like me ke ana ʻana i ʻekolu mau ʻano collagen staining, i nā biopsies endobronchial mai 17 mau mea koʻikoʻi, ʻeiwa mau haʻahaʻa, a me nā asthmatics māmā ʻehiku, a me ʻewalu mau mea hoʻomalu maʻamau.Ua nānā pū ʻia nā eosinophils a me ka transforming growth factor-beta (TGF-beta) immunoreactivity.ʻAʻohe ʻokoʻa koʻikoʻi i ka mānoanoa SBM, ka waiho ʻana o ka collagen submucosal, nā helu eosinophil, a i ʻole nā ​​cell TGF-beta maikaʻi ma waena o nā hui ʻekolu o ka asthmatics a me nā mea hoʻomalu maʻamau.ʻO ia wale nō ka nānā ʻana i nā maʻi asthmatics āpau (n = 33) i hui pū ʻia, ua ʻike ʻia kahi SBM haʻahaʻa mānoanoa (p = 0.04), e like me ka loiloi ʻia e ka collagen type III immunostaining, i ʻike ʻia i ka hoʻohālikelike ʻia me nā kumuhana mana maʻamau.ʻOiai kēia ʻokoʻa, ʻaʻohe ʻokoʻa koʻikoʻi i ʻike ʻia i ka nui o ka submucosal collagen deposition a me ka helu o nā eosinophils a i ʻole TGF-beta e hōʻike ana i nā cell i ka hoʻohālikelike ʻana i ka nui o ka asthmatics a me nā mea hoʻomalu maʻamau.Hoʻohui hou, ʻaʻohe pilina koʻikoʻi i ʻike ʻia ma waena o ka waiho ʻana o ka collagen a me ka helu eosinophil, ka pae hōʻike TGF-beta, FEV1, a i ʻole ka lōʻihi o ka hānō.Hōʻike kēia mau hopena ʻoiai ʻo ka hoʻonui ʻia ʻana o ka collagen deposition i loko o ka SBM ma ka pae ea nui he ʻano o ka hānō, ʻaʻole ia e wehewehe i nā ʻokoʻa o ka paʻakikī o ka hānō.