Nā huahana

Heparin, Sodium paʻakai he heparin polymer e hoʻopuka ana i kāna hopena anticoagulant nui ma ka hoʻoulu ʻana i ka antithrombin.Hoʻololi kēia hana i ka hoʻololi conformational ma ATIII a hiki ke hoʻonui i ka loli i kāna loop site reactive.ʻO Heparin kahi glycosaminoglycan sulfate nui i ʻike ʻia no ka pale ʻana i nā clots.ʻO Heparin, Sodium Salt kekahi mea hoʻoikaika o RyR a me ATIII.

Nā waiwai kino a me nā kemika: He keʻokeʻo a aneane keʻokeʻo ʻo Heparin sodium, ʻaʻala ʻole, hygroscopic, hiki ke hoʻoheheʻe ʻia i ka wai, hiki ʻole ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe kūlohelohe e like me ka ethanol a me ka acetone.He koʻikoʻi koʻikoʻi koʻikoʻi i loko o ka hoʻonā wai a hiki ke hui pū me kekahi mau cations e hana i nā molecular complexes.ʻOi aku ka paʻa o nā haʻina wai ma ka pH 7.

Anticoagulant: ʻO ka sodium Heparin he anticoagulant, he mucopolysaccharide, ka paʻakai sodium o ka glucosamine sulfate i unuhi ʻia mai ka mucosa intestinal o nā puaʻa, nā pipi a me nā hipa, a hūnā ʻia e nā mast cell i loko o ke kino kanaka.A aia maoli i loko o ke koko.ʻO ka sodium Heparin ka hana o ka pale ʻana i ka platelet aggregation a me ka luku ʻana, kaohi ʻana i ka hoʻololi ʻana o ka fibrinogen i ka monomer fibrin, kaohi ʻana i ka hoʻokumu ʻana o ka thromboplastin a me ka pale ʻana i ka thromboplastin i hoʻokumu ʻia, e pale ana i ka hoʻololi ʻana o ka prothrombin i thrombin a me antithrombin.Hiki i ka Heparin sodium ke hoʻopaneʻe a pale i ka coagulation koko ma ka vitro a me ka vivo.He paʻakikī loa kona ʻano hana a pili i nā loulou he nui i ke kaʻina coagulation.ʻO kāna mau hana: ①e kāohi i ke kūkulu ʻana a me ka hana o ka thromboplastin, a laila pale i ka prothrombin mai ka lilo ʻana i thrombin;②i nā kiʻekiʻe kiʻekiʻe, loaʻa iā ia ka hopena o ka pale ʻana i ka thrombin a me nā mea coagulation ʻē aʻe, e pale ana i ka fibrinogen mai ka lilo ʻana i fibrin Protein;③ hiki ke pale i ka hōʻuluʻulu a me ka luku ʻana i nā platelets.Eia kekahi, pili mau ka hopena anticoagulant o ka sodium heparin i ka radical sulfate i hoʻopiʻi ʻia i loko o kāna mole.Hiki i nā mea alkaline i ho'opi'i maika'i'ia e like me ka protamine a i 'ole toluidine blue hiki ke ho'opau i kona ho'opi'i 'ino, no laila hiki ke pale i kona anticoagulation.hopena.No ka mea hiki i ka heparin ke hoʻoikaika a hoʻokuʻu i ka lipoprotein lipase i loko o ka vivo, hydrolyze triglyceride a me ka lipoprotein haʻahaʻa haʻahaʻa o nā chylomicrons, no laila he hopena hypolipidemic pū kekahi.Hiki ke hoʻohana ʻia ka sodium Heparin e mālama i ka maʻi thromboembolic acute, disseminated intravascular coagulation (DIC).I nā makahiki i hala iho nei, ua ʻike ʻia ka heparin i ka hopena o ka wehe ʻana i nā lipids koko.Intravenous injection a hohonu intramuscular injection (a i ʻole subcutaneous injection), 5,000 a 10,000 mau ʻāpana i kēlā me kēia manawa.ʻAʻole ʻawaʻawa ʻo Heparin sodium a ʻo ke kahe koko ʻokoʻa ka pilikia nui o ka overdose heparin.ʻAʻole maikaʻi ma ka waha, pono e lawelawe ʻia e ka injection.ʻOi aku ka hoʻonāukiuki ʻana o ka hoʻokele intramuscular a i ʻole ka subcutaneous, i kekahi manawa hiki ke loaʻa nā hopena maʻi, a hiki i ka overdose ke kumu i ka hopu ʻana i ka naʻau;ʻO ka poho lauoho a me ka maʻi maʻi i kekahi manawa.Eia kekahi, hiki ke hana i nā haʻihaʻi kuʻuna.Hiki i ka hoʻohana lōʻihi ke hoʻoulu i ka thrombosis i kekahi manawa, ʻo ia paha ka hopena o ka pau ʻana o ka anticoagulase-III.Hoʻopaʻa ʻia ʻo Heparin sodium i nā mea maʻi me ka maʻi koko, ka ate koʻikoʻi a me ka renal insufficiency, hypertension koʻikoʻi, hemophilia, intracranial hemorrhage, peptic ulcer, nā wahine hāpai a me ka postpartum, nā ʻōpū visceral, trauma a me ka ʻoki.

Hoʻohana: ʻO ka noiʻi biochemical, hoʻohana ʻia e pale i ka hoʻololi ʻana o ka prothrombin i thrombin, me ka hopena antithrombotic.

Hoʻohana: ʻO ka sodium Heparin kahi lāʻau biochemical mucopolysaccharide i unuhi ʻia mai ka mucosa ʻōpū puaʻa me ka hana anticoagulant ikaika.Ua ʻike ʻo Mclcan i ka femoral mucopolysaccharide heparin i loko o ke akepaʻa mai nā ʻīlio i ka wā e aʻo ana i ke ʻano o ke koko koko.ʻO Brinkous et al.Ua hōʻike ʻia he hana anticoagulant ka heparin.Ma hope o ka hoʻohana ʻia ʻana o ka heparin ma ke ʻano he anticoagulant i nā noi lapaʻau no ka manawa mua, ua loaʻa ka manaʻo mai ka honua holoʻokoʻa.ʻOiai he mōʻaukala ʻoi aku ma mua o 60 mau makahiki i ka hoʻohana ʻana i ka lāʻau lapaʻau, ʻaʻohe huahana hiki ke hoʻololi piha iā ia a hiki i kēia manawa, no laila ʻo ia kekahi o nā lāʻau anticoagulant a me antithrombotic biochemical nui loa.Nui kona hoʻohana ʻana i ka lāʻau lapaʻau.Hoʻohana ʻia ia e mālama i ka myocardial infarction a me ka maʻi hepatitis pathogenic.Hiki ke hoʻohana pū me ka ribonucleic acid e hoʻonui i ka pono o ka hepatitis B. Hiki ke hoʻohana pū me ka chemotherapy e pale i ka thrombosis.Hiki iā ia ke hōʻemi i nā lipids koko a hoʻomaikaʻi i ka hana pale kanaka.he hopena kekahi.Loaʻa i ka hana anticoagulant factor Xa ka sodium heparin kaumaha haʻahaʻa.Ua hōʻike nā haʻawina pharmacodynamic i ka haʻahaʻa haʻahaʻa haʻahaʻa heparin sodium ka hopena inhibitory i ka hoʻokumu ʻana o ka thrombus a me ka thrombosis arteriovenous i vivo a in vitro, akā he liʻiliʻi ka hopena i ka coagulation a me ka ʻōnaehana fibrinolysis, e hopena i ka hopena antithrombotic.emi ke koko.ʻO ka heparin unfractionated kahi hui o nā amino glucan glycosides e hiki ke hoʻopanee a pale i ka coagulation koko ma ka vitro a me ka vivo.He paʻakikī kona ʻano anticoagulation, a he hopena ia i nā ʻano āpau o ka coagulation.me ka hoʻopaʻa ʻana i ka prothrombin i ka thrombin;ka pale ʻana i ka hana thrombin;pale i ka hoʻololi ʻana o ka fibrinogen i fibrin;pale i ka hōʻuluʻulu platelet a me ka luku ʻana.Hiki i ka Heparin ke hoʻohaʻahaʻa i nā lipids koko, hoʻohaʻahaʻa i ka LDL a me VLDL, hoʻonui i ka HDL, hoʻololi i ka viscosity koko, pale i nā cell endothelial vascular, pale i ka atherosclerosis, hoʻoikaika i ke kahe o ke koko, a hoʻomaikaʻi i ke kahe koko.

Hoʻohana: ʻO ka noiʻi biochemical, e pale i ka hoʻololi ʻana o ka prothrombin i thrombin.

Hoʻohana: Hoʻohana ʻia e hoʻopaneʻe a pale i ke kahe koko