Nā huahana

ʻO Interferon-induced transmembrane protein 1 (IFITM1) kekahi o nā lālā o ka ʻohana protein transmembrane i hoʻokomo ʻia.I loko o kēia noiʻi, ua hōʻike mākou i ka hoʻonui ʻia ʻana o ka ʻōlelo IFITM1 i ka maʻi maʻi colorectal kanaka (CRC) i hoʻopili nui ʻia me ka CRC lymph node a me ka metastasis mamao a me kahi pae lapaʻau ʻoi aku ka holomua.ʻO ka mea nui, ʻo ka hōʻike IFITM1 kiʻekiʻe he kumu prognostic kūʻokoʻa no ke ola maikaʻi ʻole.No ka noiʻi ʻana i nā mīkini molekala, ua hōʻike mākou ua hoʻolaha ʻia ka over-expression o IFITM1 i loko o nā cell CRC, ʻoiai ʻo ka knockdown o ka ʻōlelo IFITM1 i kāohi ʻia, ka neʻe ʻana o ka cell / invasion a me ka tumorigenicity in vitro.Eia kekahi, ua ʻike mākou iā Caveolin-1 (CAV1) ma ke ʻano he kumu i lalo o ka IFITM1-induced cell invasion, e like me ka knockdown o CAV1 abrogated siIFITM1 mediated inhibition of cell invasion in CRC cell.Eia kekahi, i loko o kahi hui CRC o nā maʻi maʻi 229, ʻo ka hōʻike ʻana o IFITM1 i hoʻohālikelike ʻia me ka ʻōlelo o CAV1.Hōʻike kēia mau hopena i ka hoʻolaha ʻana o IFITM1 i ka aggr essiveness o nā cell CRC, a he mea hōʻailona prognostic paha a me ka pahuhopu therapeutic no CRC.