Nā huahana

Ua manaʻo ʻia ʻo Idiopathic pulmonary fibrosis e pili ana i ka hōʻeha ʻana i ka ʻōpū i hoʻokumu ʻia e nā ʻano oxygen reactive (ROS), a ma hope o ka fibrosis abnormal.He mea koʻikoʻi ka hoʻonui ʻia ʻana o ka helu myofibroblast (TGF)-β1 i kēia fibrosis abnormal.Ua ʻike koke mākou ʻo ka mepenzolate bromide (mepenzolate), i hoʻohana ʻia i ka lāʻau lapaʻau no ka mālama ʻana i nā maʻi ʻōpū, loaʻa nā waiwai hoʻemi ROS.Ma ka haʻawina o kēia manawa, ua nānā mākou i ka hopena o ka mepenzolate ma ka bleomycin-induced pulmonary fibrosis a me ka maʻi ʻeha i nā ʻiole.ʻO ka paʻakikī o ka fibrosis pulmonary i loiloi ʻia e ka loiloi histopathologic a me ka hoʻoholo ʻana i nā pae hydroxyproline.Ua loiloi ʻia nā mīkini māmā (elastance) a me ka hana hanu [forced vital capacity (FVC)] me ka hoʻohana ʻana i ka ventilator e hoʻokele ʻia e ka lolouila.Ua loiloi pū ʻia ka hana hanu ma ka nānā ʻana i ka saturation oxygen arterial percutaneous (SpO2).ʻO ka lawelawe intratracheal o ka mepenzolate ma mua o ka mālama ʻana i ka bleomycin i hōʻemi i ka nui o ka fibrosis pulmonary a me nā loli i ka mīkini māmā a alakaʻi i kahi hoʻōla nui o ka FVC a me SpO2 i hoʻohālikelike ʻia me ka mana.Eia kekahi, ua hoʻopuka ka mepenzolate i kahi hopena therapeutic ʻoiai ke lawelawe ʻia ma hope o ka ulu ʻana o ka fibrosis.ʻO ka hoʻohana ʻana i ka mepenzolate ua pale pū i ka make ʻana o ka pulmonary cell i ka bleomycin-induced a me nā pane ʻeha a hoʻonui i ka helu myofibroblast.Ua emi pū ka Mepenzolate i ka hana NADPH oxidase a me ka pae TGF-β1 ikaika a i ʻole ka hoʻonui ʻana i ka hana glutathione S-transferase (GST) i mua o ka mālama ʻana i ka bleomycin.Hōʻike kēia mau hopena i ka hoʻokele intratracheal o ka mepenzolate i hōʻemi i ka bleomycin-induced pulmonary fibrosis a me ka hana ʻole o ka māmā i nā ʻiole.ʻO kēia mau hopena ma muli paha o ka hopena hoʻohiolo o kēia lāʻau i nā hana NADPH oxidase a me TGF-β1 a me kona hopena hoʻoulu i ke GST.