Nā huahana

ʻO nā wāhine me ka maʻi maʻi antiphospholipid (APS) ke piʻi aʻe ka pilikia o ka nalo ʻana o ka hāpai ʻana (RPL) a me ka preeclampsia.Hoʻololi pololei nā antiphospholipid antibodies (aPL) i ka hana trophoblast.ʻO ka mālama ʻana me ka haʻahaʻa molecular heparin (LMWH) e hōʻemi i ka pilikia o RPL akā ʻaʻole preeclampsia.Eia kekahi, hoʻoulu ʻo LMWH i ka hoʻokuʻu ʻana i ka trophoblast sFlt-1, kahi mea anti-angiogenic pili i ka preeclampsia.Ma muli o ka pili ʻana o ka nele o ka huaora D me ka APS a me ka preeclampsia, ua ʻimi kēia noiʻi e hoʻoholo i ka hopena o ka huaora D ma ka hana trophoblast i ka hoʻonohonoho ʻana o aPL a me LMWH. me ka loaʻa ʻole o ka aPL i ke alo a me ka loaʻa ʻole o ka vitamina D, LMWH a i ʻole nā ​​​​mea ʻelua.Trophoblast huna o cytokines inflammatory a me angiogenic kumu ua ana ia e ELISA.Vitamin D wale a i hui pu me LMWH attenuated ka aPL-induced trophoblast inflammatory pane i loko o nā pūnaewele HTR8 a me nā moʻomeheu mua.ʻOiai ʻaʻohe hopena o ka huaʻai D i ka modulation aPL-mediated o nā mea angiogenic i ka trophoblast mua, ua pāpā nui ia i ka hoʻokuʻu ʻana o LMWH-induced sFlt-1. ʻOi aku ka maikaʻi o ka LMWH i hui pū ʻia me ka vitamin D ma mua o ka lāʻau lapaʻau hoʻokahi ma ka pale ʻana i ka aPL. -i hoʻoulu ʻia i ka ʻeha trophoblast a me ka hoʻohuli ʻana i ka huna huna sFlt-1 LMWH.