Nā huahana

Ke noiʻi nei kēia haʻawina i ka hiki ke loaʻa i ke kolamu lua lua-lua ka ʻike ʻana i ka paepae GC piha ʻelua-dimensional (GC×2GC-MS/FID) no ka hoʻopili ʻana i ka metabola a me ka paʻi manamana lima o ka mimi ʻiole.Ua kiʻi ʻia nā laʻana mai kahi hoʻohālike murine e hoʻohālikelike ana i kahi meaʻai maʻamau maʻamau o ke Komohana e hōʻike ana i ka momona kiʻekiʻe a me ke kō (HFHS), ka mea e hoʻoulu ai i ka momona, dyslipidemia, a me ka pale ʻana i ka insulin.Ua hoʻohana ʻia nā mimi i hōʻiliʻili ʻia ma nā ʻanuʻu like ʻole o ke aʻo ʻana no ka loaʻa ʻana o ka ʻikepili pivotal a me ka hoʻohālikelike e pili ana i ke alo a me nā māhele pili o nā hōʻailona mua o ka maʻi metabolic.ʻO ka wehewehe ʻana i ka ʻikepili a me ka wehewehe ʻana i ka hana ʻana me kahi ala paʻi manamana lima holomua ʻole, me nā hiʻohiʻona kiʻekiʻe e ʻimi i nā hiʻohiʻona kūpono e helu ʻia e ka calibration maʻamau o waho.Hoʻopaʻa ʻia ka hilinaʻi o ka paʻi manamana lima ʻole e nā hopena quantitative ma nā hiʻohiʻona kūpono i koho ʻia i hōʻike i nā pākēneka o nā ʻano like ʻole me nā mea i ʻike ʻia ma ka hoʻohālikelike ʻana i ka ʻikepili maka qu antitative descriptors (2D peak-region volumes and percent of pane).ʻO nā analytes i hoʻoponopono ʻia me ka % o ka hoʻololi ʻana mai ka 30 a hiki i ka 1000, ʻo ia ka pyruvic acid, glycerol, fructose, galactose, glucose, lactic acid, mannitol a me valine.Ua hōʻike ʻia ka hoʻoponopono iho no ka malonic acid, succinic acid, alanine, glycine, a me ka creatinine.Hōʻike ʻia ka paʻi manamana lima kiʻekiʻe no ka loiloi maikaʻi ʻana i nā ʻano like ʻole i ka wā o nā hoʻokolohua, no laila e hōʻike ana i kahi mea hana hoʻohiki no nā haʻawina hoʻopili pilikino.Ma kēia pōʻaiapili, he mea hoihoi ka nānā ʻana i nā hiʻohiʻona ʻike i hoʻokae ʻole ʻia no ka lehulehu holoʻokoʻa e pili ana i nā poʻe.