Nā huahana

Ua hōʻike ʻia nā peptides i loaʻa he 8 mau hou o ka aspartate-serine-serine (8DSS) e hoʻoikaika i ka nucleation o ka calcium phosphate mai ka hopena i ka enamel kanaka.Ma ʻaneʻi ua hoʻāʻo mākou i ka hiki o 8DSS ke hoʻoikaika i ka remineralization o ka enamel demineralized i loko o ke ʻano in vitro o nā caries enamel mua.Hoʻokumu ʻia nā ʻeha caries mua i loko o nā poloka enamel bovine, a laila ua hoʻokau ʻia i ka 12 d o ka pH paikikala ma ke alo o 25 µM 8DSS, 1 g/L NaF (ka mana maikaʻi) a i ʻole buffer wale nō (ka mana maikaʻi ʻole).Ua hōʻoia ʻia ka absorption o 8DSS e X-ray photoelectron spectroscopy.Ua kālailai ʻia ka lilo ʻana o ka minerala, ka hohonu o ka liona, a me ka ʻike o ka mineral ma ka ʻili o ka ʻili a ma nā hohonu like ʻole o ke kino liona ma mua a ma hope o ke kaʻa ʻana o ka pH e ka microscopy māmā polarized a me ka microradiography transverse.ʻOi aku ka haʻahaʻa ma hope o ka hoʻoheheʻe ʻana o ka wai ma hope o ka pH cycling ma nā laʻana 8DSS ma mua o nā laʻana buffer-wale nō, a ʻoi aku ka hohonu o nā liona ma nā laʻana 8DSS.ʻO nā laʻana i mālama ʻia me 8DSS ua hōʻike ʻoi aku ka kiʻekiʻe o ka maʻiʻo mineral ma mua o nā laʻana buffer-wale nō ma ka ʻāina e hoʻonui ana mai ka papa honua (30 µm) a i ka hohonu lesion awelika (110 µm).ʻAʻole i loaʻa nā ʻokoʻa koʻikoʻi ma waena o nā laʻana i mālama ʻia me 8DSS a me nā mea i mālama ʻia me NaF.Hōʻike kēia mau ʻike he hiki i ka 8DSS ke hāpai i ka remineralization o ka enamel demineralized.