Methyl 1,2,3,4-tetra-O-acetyl-BD-glucuronate Cas:7355-18-2 98%
Helu Helu | XD90029 |
inoa mea kūʻai | methyl 1,2,3,4-tetra-O-acetyl-BD-glucuronate |
CAS | 7355-18-2 |
ʻĀpana Molekala | C15H20O11 |
Kaumaha Molecular | 376.31 |
Nā kikoʻī mālama | 2-8 °C |
Kānāwai Kūʻai Kūlike | 29389090 |
Huahana Huahana
Ka nana aku | Keokeo a Aneane keokeo pauda i ke aniani |
Hoʻāʻo | 98% |
Ua hoʻohana ʻia ʻo Methyl 1,2,3,4-tetra-O-acetyl-β-D-glucuronate i kahi noiʻi e loiloi i ka hoʻolālā a me ka synthesis o kahi derivatives glucuronide wai-soluble o camptothecin no ka maʻi kanesa prodrμg monotherapy a me ka antibody-directed enzyme prodrμg lāʻau lapaʻau.Ua hoʻohana pū ʻia i loko o kahi noiʻi e noiʻi i ka synthesis a me ke kuleana o nā glycosylthio heterocycles i loko o ka kemika carbohydrate.
ʻO ka hoʻohui ʻana o nā derivatives o ka pentopyranic acid
N4-Benzoylcytosine 1- (methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate) ua loaʻa me ka hua o 70% e ka glycosylation o ka trimethylsilyl derivative o N4-benzoylcytosine me methyl 1,2 ,3,4-tetra-O-acetyl-β-D-glucopyranuronate ma ke alo o ekolu mau mea like o SnCl4 ma ke ano condensing agent.ʻO Cytosine 1-(β-D-glucopyranosiduronamide) (IV) - ka amide o ka pentopyranic acid - ua hoʻohui ʻia i loko o ka hopena quantitative e ka ammonolysis o ka nucleoside (I).