Nā huahana

N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride he lāʻau lapaʻau i hoʻohana mau ʻia i ka mālama ʻana i ke koko kiʻekiʻe.Aia ia i ka papa o nā lāʻau i kapa ʻia ʻo ka angiotensin-converting enzyme (ACE) inhibitors. ʻO ke koko kiʻekiʻe kahi maʻi maʻamau e hiki ke hoʻonui i ka pilikia o nā pilikia olakino he nui, e like me ka maʻi puʻuwai, ka hahau ʻana, a me ka hōʻino ʻana i ke kīpē.ʻO nā mea hoʻopaneʻe ACE, e like me N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride, ua kuhikuhi pinepine ʻia e kōkua i ka hoʻohaʻahaʻa ʻana i ke koko a hoʻemi i ke kaumaha ma ka puʻuwai a nā kīʻaha koko. ʻO ka hana nui o ka hana no ka N- [(2'-cyano [1,1'biphenyl] -4-yl) methyl] -methyl ester L-valine monohydrochloride ke kāohi nei i ka hana o ka angiotensin-converting enzyme (ACE). ).ʻO ACE ke kuleana no ka hoʻololi ʻana i ka angiotensin I i angiotensin II, he vasoconstrictor ikaika, e hōʻemi i nā kīʻaha koko a hoʻonui i ke koko.Ma ke kāohi ʻana i ka ACE, kōkua kēia lāʻau lapaʻau e pale i ka hoʻokumu ʻana o ka angiotensin II, e alakaʻi ana i ka vasodilation (ka hoʻonui ʻana i nā kīʻaha koko) a me ka emi ʻana o ke koko.N-[(2'-cyano[1,1'biphenyl]-4-yl ) methyl]-methyl ester L-valine monohydrochloride lawe ʻia ma ka waha, pinepine e like me hoʻokahi manawa i kēlā me kēia lā.ʻO ke ʻano kikoʻī a me ka pinepine o ka hoʻokele ʻana e hilinaʻi ʻia i nā kumu like ʻole, me ka paʻakikī o ka hypertension a me ka pane ʻana o ke kanaka i ka mālama ʻana.Hiki ke hoʻohana wale ʻia kēia lāʻau lapaʻau a i hui pū ʻia me nā lāʻau antihypertensive ʻē aʻe no ka hoʻokō ʻana i ke kahe koko maikaʻi loa. Hiki i ka ester L-valine monohydrochloride ke hana i kekahi mau hopena ʻaoʻao i kekahi poʻe.ʻO nā hopena ʻaoʻao maʻamau ʻo ia ka dizziness, headache, dry cough, a me ka luhi.Inā hoʻomau kēia mau hopena ʻaoʻao a lilo paha i mea paʻakikī, pono ia e nīnau i kahi ʻoihana mālama ola.I nā hihia koʻikoʻi, hiki ke loaʻa nā hopena koʻikoʻi, e like me nā hopena maʻi, nā pilikia kīkī, a i ʻole angioedema (ka pehu nui o ka maka, nā lehelehe, ka ʻāʻī, a me ke alelo).Inā loaʻa kekahi hopena koʻikoʻi, pono e ʻimi koke ʻia ka lāʻau lapaʻau. e hōʻike i nā kūlana olakino a i ʻole nā ​​​​allergies i ke kauka kuhikuhi.ʻAʻole kūpono paha ka lāʻau lapaʻau i nā poʻe me ka mōʻaukala o ka maʻi ʻākeiki, ka maʻi ate, a i ʻole ka maʻi puʻuwai, no ka mea hiki ke hoʻonui i kēia mau maʻi. Ma ka hōʻuluʻulu ʻana, N-[(2'-cyano[1,1'biphenyl]-4 -yl)methyl]-methyl ester L-valine monohydrochloride he mea ho'opale ACE i ho'ohana 'ia no ka mālama 'ana i ke ki'eki'e.Ma ke kāohi ʻana i ka ACE, kōkua ia i ka hoʻonui ʻana i nā kīʻaha koko a hoʻohaʻahaʻa i ke koko.ʻO ka mālama ʻana i nā dosages i kuhikuhi ʻia, ka hahai mau ʻana me nā limahana mālama ola, a me ka nānā ʻana i nā hopena ʻaoʻao he mea nui no ka palekana a me ka hoʻohana pono ʻana i kēia lāʻau lapaʻau.He mea nui nō hoʻi ka mālama ʻana i ke ola olakino, e like me ka hoʻomaʻamaʻa maʻamau, ka ʻai kaulike, a me ka mālama ʻana i ke koʻikoʻi, e kākoʻo hou aku i ke kahe koko.