Nicotinamide Riboside Cas: 1341-23-7
| Helu Helu | XD91951 |
| inoa mea kūʻai | ʻO Nicotinamide Riboside |
| CAS | 1341-23-7 |
| ʻAno Molekalala | C11H15N2O5+ |
| Kaumaha Molecular | 255.25 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 2933199090 |
Huahana Huahana
| Ka nana aku | Pauda keʻokeʻo |
| ʻO Assay | 99% min |
Hiki ke hoʻohana ʻia ʻo Nicotinamide Riboside i ka noiʻi biological o ka gene circadian reprogramming transcriptome i loko o ka ate i ʻike ʻia nā ala metabolic o ka ʻelemakule i ka ʻiole.Hoʻonui ia i ka NAD + i ka cerebral cortex a hōʻemi i ka deterioration cognitive i kahi ʻano kiʻi transgenic o ka maʻi o Alzheimer.
ʻO Nicotinamide adenine dinucleotide (NAD+) he coenzyme koʻikoʻi, ke hoʻemi ʻia i ka NADH, lawelawe ʻo ia ma ke ʻano he mea hoʻemi e hāʻawi i nā electrons no ka phosphorylation oxidative a me ka synthesis ATP i ka mitochondria.He mea koʻikoʻi ka NAD+ no nā enzymes e like me sirtuins, ADP-ribosyltransferases (ARTs), a me Poly [ADP-ribose] polymerases (PARPs) a hoʻopau mau ʻia e kēia mau enzymes.ʻO ka lākiō NAD +/NADH he mea koʻikoʻi ia o ke kūlana redox o ke kelepona.(Verdin 2015).Ma kekahi mau helu, komo ʻo NAD a i ʻole NADP pili i ka hapaha o nā hopena kelepona āpau (Opitz Heiland 2015).Aia nā ʻāpana ʻokoʻa o NAD + i ka nucleus, mitochondria, a me cytoplasm (Verdin 2015).
Hiki ke hoʻololi ʻia ʻo Nicotinamide riboside (NR) i NAD + ma o kahi ʻanuʻu waena i hoʻololi ʻia i loko o ka nicotinamide mononucleotide (NMN) e NR kinase (Nrk) a laila i NAD + e NMNATs.Loaʻa maoli ʻia ka NR ma kekahi mau meaʻai akā ma ka nui haʻahaʻa loa (e laʻa me ka laulā micromolar haʻahaʻa).Ma ka mōʻaukala, ua paʻakikī ka loaʻa ʻana o NR ma nā huina hoʻomaʻemaʻe nui, akā mahalo i ka holomua o nā ʻano hana synthesis (Yang 2007), mai Iune 2013, ua kūʻai ʻia ma ke ʻano he meaʻai meaʻai.
