Nā huahana

ʻO ka lāʻau hoʻohaʻahaʻa momona hou a me ka lāʻau hoʻohaʻahaʻa lipid: ʻO Orlistat kahi ʻano hou o ka lāʻau paona a me ka lipid-lowering lāʻau i ʻike ʻia i kēia manawa ma ka honua.Me nā kūʻai makahiki o US $ 538 miliona, orlistat i kēia manawa noho i ka 80% o ka mākeke pohō kaumaha o ka honua, a ʻo nā kūʻai makahiki ma Hong Kong, Kina wale nō a hiki i US $ 80 miliona.ʻO ia wale nō ka lāʻau hoʻēmi kaumaha OTC ma ka honua.ʻOi aku ma mua o 40,000,000 poʻe a puni ka honua i lawe iā ia a lanakila i ke kaumaha.ʻO ia ka huahana hoʻemi kaumaha loa i kēia manawa.He kūpono no ka hoʻemi kaumaha.ʻO Orlistat kahi mea ikaika a lōʻihi i ka hana gastrointestinal lipase inhibitor.Ma ka pale pololei ʻana i ka ʻai ʻana o ke kino i ka momona i ka meaʻai, i ka manawa e emi ai ka ʻai ʻana o nā calorie a me ka momona ma mua o ka ʻai ʻana, hoʻemi maoli ʻia ka momona o ke kino, i mea e hoʻokō ai i ke kumu o ke kaumaha.He palekana ka lilo ʻana o ke kaumaha, ʻaʻole i komo nā mea hana i ke kahe koko, a ʻaʻole e hana i ka ʻōnaehana nerve waena.

ʻO Orlistat he mea hana lōʻihi a ikaika hoʻi i ka gastrointestinal lipase inhibitor, keʻokeʻo a i ʻole keʻokeʻo keʻokeʻo i ka lumi wela, hiki ʻole ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka chloroform, a maʻalahi hoʻi i ka ethanol.Hoʻokumu nā wahi serine ikaika o ka lipase ʻōpū a me ka lipase pancreatic i nā paʻa covalent e hoʻopau i nā enzymes.ʻAʻole hiki ke hoʻoheheʻe ʻia ka momona i loko o ka meaʻai i loko o nā ʻakika momona manuahi a me nā monoacylglycerols, no laila ʻaʻole hiki ke hoʻomoʻa ʻia ka momona a hoʻohana ʻia, ma laila e hōʻemi ai i ka lawe ʻana i ka calorie o ke kino a me ka mālama ʻana i ke kaumaha o ke kino.ʻAʻole koi kēia lāʻau lapaʻau i ka systemic absorption e hana.I ka maʻamau maʻamau, hiki ke kāohi ʻia ka absorption o ka momona e 30%.ʻAʻole hiki ke hoʻopili ʻia ma hope o ka lawelawe waha, a hiki ke hoʻopau ʻia e ka metabolism i loko o ka ʻāpana ʻōpū.Aia ka pae metabolic ma ka paia o ka ʻōpū o ka ʻōpū, a ʻo ka hoʻopau ʻana i ka hapalua ola ma kahi o 14 a 19 mau hola.Ma kahi o 97% o kēia huahana e hoʻokuʻu ʻia me nā feces, kahi o 83% i hoʻokuʻu ʻia i kona ʻano kumu.

Hiki ke hoʻohana ʻia i ka lāʻau lapaʻau i ka momona a me ka hyperlipidemia.Ma lalo o nā kūlana maʻamau, hiki ke lawe waha ʻia kahi maʻi o 120 mg, ʻekolu manawa i ka lā, me ka ʻai a i ʻole 1 hola ma hope o ka ʻai.Hiki ke emi iho ke kaumaha ma hope o 2 pule o ka lawe ʻana i ka lāʻau.Hiki ke lawe mau no 6 a 12 mahina.Inā hoʻonui ʻia ka nui ma mua o 400 mg i kēlā me kēia lā, ʻaʻole e hoʻonui hou ʻia kona hopena.