p-hydoxybenzoic acid, monosodium Cas: 114-63-6 99% Keʻokeʻo i ka pauka ʻeleʻele ʻeleʻele a i ʻole keʻokeʻo keʻokeʻo.
| Helu Helu | XD90141 |
| inoa mea kūʻai | p-hydoxybenzoic acid, monosodium |
| CAS | 114-63-6 |
| ʻĀpana Molekala | C7H5O3Na |
| Kaumaha Molecular | 160.10 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 2918290000 |
Huahana Huahana
| Ka nana aku | Keʻokeʻo i ka melemele ʻeleʻele a i ʻole ka pauka crystalline keʻokeʻo |
| ʻO Assay | ≥ 99% |
| ʻO ka mānoanoa | 1.3750 |
| Lae hehee | >300 °C(māmā) |
| Lae paila | 336.2°Cat760mmHg |
| Kuhikuhi uila | 171.3°C |
Ua noiʻi ʻia ka pale ʻana o nā β-carbonic anhydrases (CAs, EC 4.2.1.1) mai nā fungi pathogenic Cryptococcus neoformans (Can2) a me Candida albicans (Nce103) me kahi moʻo o 25 branched aliphatic a aromatic carboxylates.Ua hoʻokomo pū ʻia nā isoforms kanaka hCA I a me II i ka haʻawina no ka hoʻohālikelike.ʻO nā carboxylates aliphatic ma ke ʻano he millimolar hCA I a me II mea hoʻopaneʻe a me ka haʻahaʻa micromolar/submicromolar β-CA inhibitors.ʻO nā carboxylates Aromatic nā mea hoʻopaneʻe micromolar o nā enzyme ʻehā akā ua hōʻike kekahi o lākou i ka hana nanomolar haʻahaʻa e kūʻē i nā enzyme pathogenic fungal.ʻO 4-Hydroxy- a me 4-methoxy-benzoate i kāohi iā Can2 me K (I) s o 9.5-9.9 nM.ʻO nā methyl esters, hydroxamates, hydrazides a me nā carboxamides o kekahi o kēia mau derivatives he mau mea hoʻopiʻi maikaʻi hoʻi o nā α- a me β-CA i noiʻi ʻia ma aneʻi.
ʻO nā parabens kekahi o nā mea mālama i hoʻohana pinepine ʻia e kāohi i ka ulu ʻana o ka microbial a hoʻolōʻihi i ke ola o ka nui o nā huahana mea kūʻai aku.ʻO ka pahuhopu o kēia haʻawina ʻo ia ka loaʻa ʻana o ka ʻike i ka metabolism o nā parabens i loko o nā pūnaʻi maʻi maʻi umauma (MCF7) no ka mea ua hōʻike lākou i ka hana estrogenic i kēia mau cell a ua ʻike ʻia i loko o nā ʻiʻo maʻi maʻi umauma.Ua hoʻoholo ʻia ka ʻona o nā parabens i nā pūnaewele MCF7 me ka hoʻohana ʻana i nā hōʻike MTT.ʻO ka hydrolysis o methyl-, butyl a me benzyl-paraben i ka p-hydroxybenzoic acid i kālailai ʻia i loko o nā pūnaewele MCF7 moʻomeheu a me nā homogenates cellular.Ua aʻo ʻia ka Glucuronidation a me ka sulfoconjugation i nā homogenates MCF7, a ua nānā ʻia nā parabens e HPLC.Ua hōʻike ʻia ʻo Methyl-paraben he mea ʻawaʻawa loa ma mua o ka butyl a me benzyl-paraben.Ua paʻa loa nā parabens i nā homogenates MCF7 aʻo ka p-nitrophenyl acetate, kahi ʻano substrate, i ka hydrolysis.ʻAʻole hōʻike ʻia nā homogenates cell MCF7 i ka glucuronidation a me nā hana sulfoconjugation i nā parabens.ʻO ke kūpaʻa kiʻekiʻe o nā parabens e wehewehe i ko lākou hōʻiliʻili ʻana i ka ʻiʻo maʻi maʻi umauma.
![N-[[bis[4-(dimethylamino)phenyl]amino]carbonyl] glycine sodium paʻakai Keʻokeʻo a hiki i ka pauka aniani ʻōmaʻomaʻo hina.](http://cdn.globalso.com/xdbiochems/115871-19-7.jpg)
