Polymyxin B sulfate CAS:1405-20-5 ʻO ka pauka keʻokeʻo
| Helu Helu | XD90360 |
| inoa mea kūʻai | Polymyxin B sulfate |
| CAS | 1405-20-5 |
| ʻĀpana Molekala | C55H96N16O13 · 2H2SO4 |
| Kaumaha Molecular | 1385.61 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 29419000 |
Huahana Huahana
| Ka hopena | Kūlike me USP35 |
| Nā metala kaumaha | <20ppm |
| pH | 5-7 |
| ʻIkepili | Kromatography wai: conforms |
| Hoʻāʻo | 99% |
| Ka nana aku | Pauda keʻokeʻo |
| Nalo ma ka maloo | <6% |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i ka Ethanol |
| Sulfate | 15.5% - 17.5% |
| Ka nui o ka ʻāpana | <30µm |
| ʻO ka hoʻololi ʻana i ka optical kikoʻī | -78° -90° |
| Phenylalanine | 9.0%-12.0% |
| Pyrogens | Kū i nā koi |
| Lehu hū | <0.75% |
| Huina aerobic hiki ke ola | <100cfu/g |
| Ka mana | >6500 IU/mg |
ʻO ka ExPortal protein secretion organelle ma Streptococcus pyogenes kahi anionic phospholipid-containing membrane microdomain i hoʻonui ʻia i nā Sec translocons a me nā kumu biogenesis protein postsecretion.Hoʻopaʻa ʻia ka Polymyxin B a hoʻopau i ka pono o ExPortal, ka hopena o ka huna ʻana o kekahi mau toxins.No ka loaʻa ʻana o ka ʻike i nā mea e hoʻoikaika ai i ka hui ʻo ExPortal, ua alakaʻi ʻia kahi pale genetic e koho ai no nā mutants kūʻokoʻa polymyxin B-resistant e hōʻike ana i ka pono ExPortal i hoʻonui ʻia.Hōʻike ʻia ka hoʻihoʻi ʻana o ka genome holoʻokoʻa o 25 mau mutants kūpaʻa mai hoʻokahi a ʻehā mau mutation no kēlā me kēia genome mutant i hui nui ʻia i loko o kahi pūʻulu kumu o nā pūʻulu gene 10.ʻO ke kūkulu ʻana i nā mutants me ka holoi ʻana a i ʻole nā hoʻokomo ʻana i hōʻike ʻia he 7 mau genes kumu e hāʻawi i ke kūpaʻa a hoʻonui i ka pono ExPortal ma o ka nalowale o ka hana, ʻoiai ʻo 3 ma muli o ka loaʻa ʻana o ka hana a/a i ʻole nā hopena hui.Loaʻa i nā genes resistance core kahi mea hoʻoponopono transcriptional o ka biosynthesis lipid, kekahi mau genes i komo i ka loaʻa ʻana o ka meaʻai, a me nā ʻano genes i komo i nā pane pilikia.ʻElua mau lālā o ka papa hope e hana pū me nā mea hoʻoponopono hou o ka SpeB cysteine protease huna.ʻO ka loiloi o ka mutation hoʻokaʻawale pinepine ʻia, kahi holoi nucleotide hoʻokahi i ke ala o 9 mau koena adenine i pstS, e hoʻopili ana i kahi ʻāpana o kahi transporter Pi pili kiʻekiʻe, e hōʻike ana i kēia kaʻina hana e like me ka hoʻololi molekala e hoʻomaʻamaʻa i ka hoʻololi ʻana i ke kaumaha.ʻO ka hui pū ʻana, hōʻike kēia mau ʻikepili i ke ʻano o kahi pane koʻikoʻi o ka membrane e hāpai i ka hoʻomaikaʻi ʻana i ka pono ExPortal a me ke kūʻē ʻana i nā peptides antimicrobial cationic.
