Nā huahana

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine he hui chiral me nā noi like ʻole ma ke kahua o nā lāʻau lapaʻau. -N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine aia i ka hoʻomohala ʻana i nā mea hoʻopiʻi reuptake serotonin koho (SSRIs).ʻO SSRI kahi papa o nā lāʻau lapaʻau i hoʻohana mau ʻia e mālama i ke kaumaha, nā pilikia hopohopo, a me nā kūlana olakino ʻē aʻe.Ke hana nei kēia pūhui ma ke ʻano he precursor a i ʻole ka mea hoʻomaka i ka synthesis o selective serotonin reuptake inhibitors, e ʻae ana i ka hoʻomohala ʻana i nā enantiomers kūikawā me nā waiwai therapeutic hoʻonui.Ma ka hoʻokomo ʻana i (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine i loko o ke ʻano o ka lāʻau lapaʻau, hiki i nā mea noiʻi ke hoʻololi i kāna mau waiwai pharmacological, e like me kona pili ʻana i nā mea lawe serotonin, ka hopena i ka hoʻomaikaʻi maikaʻi ʻana a me ka hōʻemi ʻana i nā hopena ʻaoʻao. pūhui.ʻO kona ʻano chiral a me kona ʻano hana maʻalahi e lilo ia i mea hoʻomaka waiwai no ke kūkulu ʻana i nā molekala paʻakikī.Hiki i nā mea noiʻi ke hana i nā wahi like ʻole ma ka mole e hoʻolauna i nā hui like ʻole a hoʻololi paha i kāna stereochemistry e hana i nā moho lāʻau lapaʻau hou. ua aʻo ʻia no kona hoʻohana ʻana i ka mālama ʻana i ka maʻi o Parkinson.Ua hōʻike ʻia ka noiʻi e hōʻike ana kēia pūhui i ka hana agonist dopamine, ʻo ia ka mea hiki ke hoʻoulu i nā mea loaʻa dopamine, i hoʻopilikia pinepine ʻia i ka maʻi o Parkinson.Loaʻa paha iā ia ka mana therapeutic i ka hoʻohaʻahaʻa ʻana i nā hōʻailona pili i kēia maʻi neurodegenerative. hoʻohuihui, a pono e mālama ʻia me ka akahele.Pono nā mea noiʻi a me nā poʻe loea e hana pū ana me kēia pūhui e mālama i nā alakaʻi palekana a me nā kaʻina hana e hōʻoia i ka mālama pono ʻana a me ka hōʻemi ʻana i nā pilikia. ʻO ka propanamine he mea waiwai nui i ka hoʻomohala ʻana i nā mea hoʻopaneʻe reuptake serotonin koho a me nā molekole bioactive ʻē aʻe.ʻO kona ʻano chiral, ʻano hana maʻamau, a me nā hana therapeutic hiki ke lilo ia i mea koʻikoʻi hale i ka noiʻi lāʻau lapaʻau.ʻO ka hoʻomau ʻana i ka noiʻi a me ka ʻimi ʻana o (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine hiki ke kōkua i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a me nā lāʻau lapaʻau kūpono no nā maʻi like ʻole.