Spiramycin Cas: 8025-81-8
| Helu Helu | XD90452 |
| inoa mea kūʻai | ʻO Spiramycin |
| CAS | 8025-81-8 |
| ʻĀpana Molekala | C43H74N2O14 |
| Kaumaha Molecular | 843.05 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 29419000 |
Huahana Huahana
| Ka nana aku | Pauda keʻokeʻo |
| Hoʻāʻo | >4100IU/mg |
| Nā metala kaumaha | <20ppm |
| Nalo ma ka maloo | < 3.5% |
| Lehu Sulphated | < 1.0% |
| Ethanol | < 2.0% |
| ʻO ka hoʻololi ʻana i ka optical kikoʻī | -85 a i -80 deg |
Hoʻokumu ʻo Streptomyces ambofaciens i ka macrolide antibiotic spiramycin.Ua hōʻike ʻia ka pūʻulu gene biosynthetic no ka spiramycin no S. ambofaciens.Ma waho aʻe o ka gene regulatory srmR (srm22), i ʻike mua ʻia (M. Geistlich et al., Mol. Microbiol. 6:2019-2029, 1992), ʻekolu mau genes regulatory putative i ʻike ʻia e ka nānā ʻana.Hōʻike ka hōʻike hōʻike Gene a me nā hoʻokolohua inactivation gene i hoʻokahi wale nō o kēia mau genes ʻekolu, srm40, ke kuleana nui i ka hoʻoponopono ʻana i ka biosynthesis spiramycin.ʻO ka hoʻopau ʻana o srm22 a i ʻole srm40 i hoʻopau i ka hana spiramycin aʻo kā lākou overexpression hoʻonui i ka hana spiramycin.Ua hana ʻia ka hōʻike hōʻike e ka reverse transcription-PCR (RT-PCR) no nā genes a pau o ka puʻupuʻu i loko o ke ʻano wild-type strain a ma ka srm22 (srmR) a me ka srm40 holoi ʻana i nā mutants.ʻO nā hualoaʻa mai ka hōʻike hōʻike, a me nā mea mai nā hoʻokolohua hoʻohui, ua hōʻike ʻia e koi ʻia ʻo Srm22 no ka hōʻike srm40, ʻo Srm40 kahi mea hoʻoulu ala e hoʻomalu i ka hapa nui, inā ʻaʻole nā mea āpau, o nā genes biosynthetic spiramycin.
