Nā huahana

No ka noiʻi ʻana i ka hopena o ka ʻaila spearmint ma nā hoʻololi e like me ka emphysema a me ka hōʻike ʻana o ka tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) a me ka mea hoʻopaʻa paʻa o ka metalloproteinase. -1 (TIMP-9) i loko o ka lipopolysaccharide (LPS) i mālama ʻia i nā ʻiole. Emphysematous nā hoʻololi hoʻohālike i hoʻokomo ʻia e ka intratracheal instillation o LPS hoʻokahi manawa i ka pule a hiki i ka 8 pule i nā ʻiole.Ua māhele ʻia nā ʻiole i ka mana, dexamethasone (0.3 mg x kg(-1)), a me ka ʻaila spearmint (10, 30,100 mg x kg(-1)) pūʻulu.Ua mālama ʻia kēlā me kēia hui me ka saline, dexamethasone, a me ka ʻaila ihe no 4 pule.A laila ua hoʻokō ʻia nā helu keʻokeʻo keʻokeʻo holoʻokoʻa i loko o ka bronchoalveolar lavage fluid (BALF).ʻO nā loli pathologic o ka ʻiʻo māmā e like me ke ʻano o ka alveolar, ka ʻāʻī o ke ea, a me ka metaplasia cell goblet i ʻike ʻia e HE a me AB-PAS staining.Ua anaʻia ka hōʻikeʻana o TNF-alpha, IL-1beta, TIMP-1 a me MMP-9. ʻO ka spearmint a me ka dexamethasone i ho'ēmi i ka lukuʻana i ka pulmonary alveolus.ʻO ka nui a me nā helu keʻokeʻo keʻokeʻo like ʻole ma BALF me ka neutrophile a me ka lymphocyte o ka ʻaila spearmint 100 mg x kg(-1) a me ka hui dexamethasone ua hoʻemi nui ʻia, a ua kāohi pū ʻia ka metaplasia cell goblet.Ua loaʻa i ka Dexamethasone ka hopena pale i ka hōʻike o TNF-alpha, IL-1beta, TIMP-1 a me MMP-9.ʻO ka ʻaila Spearmint 30, 100 mg x kg(-1) i hoʻemi nui i ka TNF-alpha a me ka IL-1beta.ʻAʻohe hopena o ka ʻaila Spearmint 10, 30 a me 100 mg x kg (-1) i ka hōʻike ʻana o TIMP-1, akā hiki ke hoʻemi nui i ka hōʻike ʻana o MMP-9 i nā ʻiʻo māmā. no ka mea, hoʻomaikaʻi ia i ka luku ʻana i ka alveolar, ka mumū o ka pulmonary, a me ka metaplasia cell goblet.Hiki i ka mīkini ke hoʻemi i ka TNF-alpha, IL-1beta maʻiʻo a me ka pale ʻana i ka overexpression o ka matrix metalloproteinase-9 i loko o nā ʻiʻo māmā.