Uridine-5′-diphosphoglucuronic acid trisodium paʻakai CAS:63700-19-6 Pauka keʻokeʻo
| Helu Helu | XD90382 |
| inoa mea kūʻai | Uridine-5'-diphosphoglucuronic acid trisodium paʻakai |
| CAS | 63700-19-6 |
| ʻĀpana Molekala | C15H19N2O18P2Na3 |
| Kaumaha Molecular | 646.20 |
| Nā kikoʻī mālama | < -4 °C |
Huahana Huahana
| Hoʻāʻo | 99% |
| Ka nana aku | Pauda keʻokeʻo |
Ke manaʻo nei ka noiʻi e noiʻi i ka mana o ka ʻawaʻawa o irinotecan e ka biotransformation o glucoaurantio-obtusin i aurantio-obtusin.ʻO ka lawelawe intraperitoneal (ip) o 100 mg/kg aurantio-obtusin i hoʻonui nui i ka ʻawaʻawa o ka irinotecan, akā ʻo ka hoʻohana ʻana i ka ip o 100 mg/kg glucoaurantio-obtusin i hōʻike ʻole i ka hopena o ka ʻona o irinotecan.Eia kekahi, ua wehewehe ʻia ke ʻano hana ma o ka hoʻoholo ʻana i ka hiki o ka inhibition o glucoaurantio-obtusin a me aurantio-obtusin i ka glucuronidation metabolism o SN-38 i manaʻo ʻia ʻo ia ka huahana ikaika nui e pili ana i ka ʻona o ka irinotecan.Ua hōʻike ʻia nā hopena i hōʻike ʻia ka aurantio-obtusin i ka hoʻokūkū hoʻokūkū ikaika i ka glucuronidation o SN-38, akā ʻike ʻia ka hiki ʻole o ka inhibition o ka glucoaurantio-obtusin i ka glucuronidation SN-38.Ua hōʻike kēia mau hopena i ka biotransformation o glucoaurantio-obtusin e pili ana i ka aurantio-obtusin i hoʻonui i ka ʻawaʻawa o ka irinotecan ma o ka hoʻonui ʻia ʻana o ka SN-38 glucuronidation.
