Nā huahana

ʻO Nickel kahi mea e hoʻoholo ai i ka virulence no ka maʻi ʻōpū o ke kanaka Helicobacter pylori.ʻOiaʻiʻo, loaʻa iā H. pylori nā nickel-enzymes ʻelua e pono ai no ka noho ʻana i loko o ke ola, [NiFe] hydrogenase a me ka urease, kahi mea virulence nui i loaʻa he 24 nickel ions no kēlā me kēia complex active.Ma muli o kēia mau enzyme ʻelua, hilinaʻi ke ola o H. pylori i kahi lako nickel koʻikoʻi, e hōʻike ana i ka hoʻomalu paʻa ʻana o kāna hoʻolaha a mālama ʻana.Ma kēia loiloi, e hōʻike mākou i nā ala o ka hoʻoulu ʻana o nā enzyme nickel a me nā mīkini kumu i loaʻa ma H. ​​pylori no ka lawe ʻana, kālepa a me ka hāʻawi ʻana i ka nickel ma waena o nā enzyme ʻelua.Loaʻa kēia mau mea (i) kahi ʻōnaehana nickel uptake o waho, ka FrpB4 TonB-dependent transporter, (ii) overlapping protein complexes a me ka launa pū ʻana i pili i ke kālepa nickel a me ka hāʻawi ʻana ma waena o ka urease a me ka hydrogenase a, (iii) Helicobacter specific nickel-binding proteins i komo i loko o ka waihona nickel a hiki ke pāʻani i ka hana o nā metallo-chaperones.ʻO ka hope, e kūkākūkā mākou i ka hopena o nā hoa kalepa nickel i loko o ka virulence a hoʻolauna iā lākou i mau pahuhopu therapeutic novel no ka mālama ʻana i ka maʻi H. pylori.