Nā huahana

ʻO 5,6-Dihydro-3-(4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone, i kapa ʻia ʻo DPHP, he hui heterocyclic me nā noi like ʻole. i ka lāʻau kemika a me ka ʻike lāʻau.Eia ka wehewehe ʻana o kāna hoʻohana ʻana ma kahi o nā huaʻōlelo 300. Ua ʻike ʻia ʻo DPHP no kona hiki ke hoʻopaʻa i ka ikaika a koho i kekahi mau enzymes a me nā mea loaʻa i loko o ke kino kanaka.ʻO kekahi o kāna mau noi mua ma ke kahua o ka kinase inhibition.ʻO Kinases nā enzyme e hana koʻikoʻi i nā ala hōʻailona cell a pili pinepine i nā maʻi like ʻole, me ka maʻi kanesa.Ua ʻike ʻia ʻo DPHP e hoʻokaʻawale i nā kinases kikoʻī, a laila e hoʻopau i nā cascade hōʻailona aberrant e kōkua i ka piʻi ʻana o ka maʻi.ʻO kēia ka mea i hoʻohiki ʻia no ka hoʻomohala ʻana i nā lāʻau lapaʻau i hoʻopaʻa ʻia no nā ʻano maʻi like ʻole, me ka maʻi kanesa, ka mumū, a me nā maʻi neurological.ʻO ka hū he pane kūlohelohe ia o ke kino i ka maʻi a i ʻole ka hōʻeha akā hiki ke lilo i mau maʻi a alakaʻi i nā maʻi like ʻole.Ua hōʻike ʻo DPHP i ka hiki ke kāohi i kekahi mau ala pro-inflammatory, e hōʻemi ana i ka hana ʻana o nā mea hoʻolaha inflammatory.Hoʻolilo kēia waiwai i mea waiwai nui i ka hoʻomohala ʻana i nā lāʻau anti-inflammatory, kōkua i ka mālama ʻana i nā kūlana e like me ka rheumatoid arthritis, ka maʻi ʻeha o ka ʻōpū, a me ka hānō. .He pilikia olakino koʻikoʻi ka ʻeha ʻeha, a he mau palena a i ʻole nā ​​hopena ʻaoʻao makemake ʻole nā ​​koho lapaʻau o kēia manawa.Ua hōʻike ʻo DPHP i nā hopena analgesic i nā haʻawina preclinical, e hōʻike ana i kona hiki ke ʻano he therapeutic novel no ka mālama ʻana i ka ʻeha.Ma ka hoʻololi ʻana i nā mea loaʻa kūikawā a me nā neurotransmitters e pili ana i ka ʻeha ʻeha, hiki i ka DPHP ke hāʻawi i kahi ala ʻē aʻe i ka mālama ʻana i ka ʻeha me ka liʻiliʻi o nā hopena ʻaoʻao.ʻO nā kūlana neurological e like me ka maʻi o Alzheimer a me ka maʻi o Parkinson e pili ana i nā mīkini paʻakikī a me ka dysregulation o nā ʻokoʻa like ʻole a me nā enzymes i loko o ka lolo.Ua aʻo ʻia ʻo DPHP no kona hiki ke lilo i mea hana neuroprotective a no kona hiki ke hoʻonui i ka hana cognitive.Ma ka huli ʻana i nā mea loaʻa a me nā ala e pili ana i nā maʻi neurodegenerative, paʻa ʻo DPHP i ka ʻōlelo hoʻohiki ma ke ʻano he therapeutic intervention no kēia mau kūlana paʻakikī. ʻO ka 1-piperidinyl) phenyl] -2 (1H) -pyridinone (DPHP) he hui nui me nā noi kūpono i ka kinase inhibition, anti-inflammatory activity, analgesia, a me neuroprotection.ʻO kona hiki ke hoʻololi i nā enzyme kikoʻī a me nā mea loaʻa i komo i nā ala maʻi e lilo ia i moho maikaʻi no ka ʻike ʻana i ka lāʻau lapaʻau a me ka therapeutic intervention.Hiki i ka noiʻi a me ka hoʻomohala hou ke wehe i nā hoʻohana hou a hoʻopaʻa i kāna mau waiwai no nā hōʻailona kikoʻī.