Nā huahana

6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride he hui me nā noi kūpono i ka noiʻi lāʻau lapaʻau a me ka hoʻomohala lāʻau.Hāʻawi ʻia kona ʻano molekala kūikawā i nā manawa no ka hoʻokolokolo ʻana i kāna mau hoʻohana therapeutic. No ka ʻohana pyrido [2,3-d] pyrimidinone kēia pūhui, i aʻo nui ʻia no kāna mau hana lāʻau lapaʻau.ʻO ka hiki ʻana o ka hui acetyl e hōʻike ana i nā pilina pili me nā enzyme i komo i nā kaʻina cellular.Loaʻa paha ia i nā hopena pale i nā enzymes e like me kinases a i ʻole proteases, e lilo ia i moho hoʻohiki no ka hoʻomohala ʻana i nā mea hoʻokae kikoʻī enzyme.Hāʻawi kēia waiwai iā ia e hele maʻalahi i nā pale olaola, e hoʻonui ana i kona hiki ke lilo i moho lāʻau.Hiki paha ke hoʻonui i ka permeability a me ka bioavailability, e kūpono ana i ka hoʻoponopono waha a me ka hoʻolaha pūnaewele. ʻO nā hui 1-piperazinyl a me 2-pyridinyl i loko o ka pūhui e hāʻawi i ka versatility no kona hoʻohana ʻana i ka hoʻolālā lāʻau.Ua ʻike nui ʻia nā derivatives Piperazine i ka kemika lāʻau lapaʻau no kā lākou hana olaola.Hiki i ka hui piperazine ke kōkua i ka hoʻopaʻa ʻana a me ka hoʻololi ʻana i nā waiwai pharmacokinetic.Eia kekahi, pili pinepine ka hui pyridine i nā pilina ligand-receptor, no ka mea, hiki i nā ʻōnaehana apo pyridine ke hoʻokumu i nā paʻa hydrogen me nā pūnaewele loaʻa kikoʻī.ʻO kēia mau waiwai e hoʻolilo i kēia pūhui i ligand kūpono no nā mea loaʻa like ʻole, e komo pū me nā mea hoʻokipa G protein-coupled. No ka noʻonoʻo ʻana i ka pyrido [2,3-d] pyrimidinone scaffold a me ka hele ʻana o ka hui piperazine, hiki ke ʻimi ʻia ka hui ma ke ʻano he anti-cancer agent. .Hiki iā ia ke hōʻike i nā hopena cytotoxic e kūʻē i nā maʻi maʻi maʻi ma o ke kāohi ʻana i nā ala hōʻailona kikoʻī e pili ana i ka hoʻonui ʻana o ke kelepona.ʻO nā haʻawina hou e pili ana i nā hiʻohiʻona in vitro a me in vivo hiki ke loiloi i kona hiki ke lilo i mea anti-tumor.Ma ka hoʻokomoʻana i nā hui hana kūpono a iʻole nā ​​mea pani, hiki ke hoʻonuiʻia kona koho a me kona ikaika, eʻae ai i ka hoʻomohalaʻana i nā mea lapaʻau kūikawā kūikawā. piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-hoʻokahi hydrochloride paʻa i nā wahi he nui o ka noiʻi lāʻau lapaʻau.ʻO kāna mau hiʻohiʻona e ʻae ai i ka hoʻokolokolo ʻana i ka hoʻopaʻa ʻana i ka enzyme, ka hoʻopaʻa ʻana i ka mea hoʻokipa, a me ka hana anti-cancer.ʻO ka ʻimi hou ʻana a me ka hoʻonui ʻana i kāna ʻano kumu e hiki ai ke hoʻopuka i nā moho lāʻau lapaʻau hou me ka hoʻomaikaʻi maikaʻi ʻana a me ka kikoʻī no nā pahuhopu therapeutic like ʻole.