Nā huahana

ʻAʻole hiki i ka hapa nui o nā lāʻau anticancer ke hoʻopau i nā maʻi koko, e alakaʻi ana i ka hoʻomohala ʻana i ka lāʻau kūʻē a me ka hoʻi hou ʻana o ka maʻi.He kuleana koʻikoʻi ka hōʻailona Hedgehog i ka wā o ka ulu ʻana o ka embryonic, akā pili pū kekahi i ka hoʻomohala ʻana i ka maʻi kanesa, ka holomua, a me ka metastasis.ʻO ka Hedgehog receptor Patched (Ptc) he Hedgehog signaling target gene i hōʻike nui ʻia i nā maʻi kanesa he nui.Maanei, hōʻike mākou i kahi loulou ma waena o Ptc a me ke kū'ē i ka chemotherapy, a hāʻawi i ka ʻike hou i ka hana Ptc.Hoʻomaʻemaʻe ʻia ʻo Ptc mai ka membrane plasma ma ka launa pū ʻana me kāna ligand Hedgehog, a i ʻole ma ka mālama ʻana i nā cell me ka Hedgehog hōʻailona antagonist cyclopamine.I nā hihia ʻelua, ma hope o ka incubation o nā cell me doxorubicin, kahi mea chemotherapeutic i hoʻohana ʻia no ka mālama ʻana i nā maʻi maʻi maʻi hou, ʻike mākou i ka pale ʻana i ka efflux o doxorubicin mai nā fibroblasts pane ʻo Hedgehog, a me ka piʻi ʻana o ka doxorubicin accumulation i nā maʻi maʻi ʻelua. nā laina kelepona i ʻike ʻia e hōʻike i nā pae aber rant o nā ʻāpana hōʻailona Hedgehog.Ke hoʻohana nei i ka ʻōnaehana hōʻike heterologous, ua hōʻike ikaika mākou i ka hōʻike ʻana o ke kanaka Ptc i ke kūʻē ʻana i ka ulu ʻana o ka ulu ʻana e kekahi mau lāʻau lapaʻau mai nā lāʻau chemotherapeutic e like me doxorubicin, methotrexate, temozolomide, a me 5-fluorouracil.Hoʻopili ʻia ke kūʻē ʻana i ka doxorubicin me ka hana Ptc, e like me ka mea i hōʻike ʻia me ka hoʻohana ʻana i nā hoʻololi ʻana mai nā maʻi maʻi o Gorlin's syndrome kahi i nalowale ai ka hopena Ptc-mediated ma ka hōʻailona Hedgehog.Hōʻike kā mākou hopena e pili ana ʻo Ptc i ka lāʻau efflux a me ka pale ʻana i nā lāʻau multidrug, a ke manaʻo nei e kōkua ʻo Ptc i ka pale ʻana i ka chemotherapy o nā maʻi kanesa.