Nā huahana

Ua hōʻike ʻia kahi metabolite bacterial o ka ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol (hui K), e hoʻoulu i ka apoptosis i loko o nā ʻano maʻi kanesa.Eia nō naʻe, ʻaʻole maopopo nā ʻano hana pololei i hoʻokomo ʻia e ka hui K i loko o ke kanaka hepatocellular carcinoma (HCC).I mea e nānā ai i nā hana apoptotic hiki, ua noiʻi mākou i ka hopena anticancer o ka hui K ma MHCC97-H.Ua hōʻike ka MTT assay i ka pūhui K i kaohi i ka hoʻonui ʻana o nā pūnaewele MHCC97-H me ka haʻahaʻa haʻahaʻa o ka ʻona i loko o nā pūnaewele hepatoma maʻamau.Ua hōʻike ʻia ka piʻi ʻana o ka haʻihaʻi sub-G1 apoptotic i ka holomua ʻana o ka cell cycle a me ka cell staining.ʻO ka hoʻomaʻamaʻa ʻana o MHCC97-H me ka pūhui K i hoʻoulu ʻia i ka hōʻemi ʻana i ka hikiwawe membrane mitochondrial (Δψm) a me ka pōʻino DNA.Ua hōʻike hou ʻia kahi noiʻi ʻana i ka hui K upregulated Fas, FasL, Bax/Bcl-2 ratio a me downregulated pro-caspase-9, pro-caspase-3 ma ke ʻano o ka hoʻopaʻa ʻana, a ua kāohi pū ʻo ia i ka phosphorylation Akt.Ke hōʻike nei kēia mau hopena i ka mea K hoʻopili nui i ka hoʻonui ʻana o ka cell a hoʻoulu i ka apoptosis i loko o nā pūnaewele MHCC97-H ma o Fas- a me ka mitochondria-mediated caspase-dependent alahele i loko o nā pūnaewele HCC kanaka.