Nā huahana

Hoʻokomo ʻia ʻo Melatonin i nā hana physiological he nui, a he ʻokoʻa kona hopena i ka apoptosis i nā maʻi maʻamau a me nā maʻi kanesa.Eia nō naʻe, ʻaʻole maopopo i ke ʻano o kāna hana antitumor.Ma kēia haʻawina, hōʻike mākou i ka hoʻonui ʻana o ka melatonin i ka apoptosis i hoʻokomo ʻia i ka tunicamycin i loko o nā pūnaʻi MDA-MB-231 umauma umauma kanaka.Hoʻoponopono ʻo Melatonin i ka pro-apoptotic protein Bim i nā pae transcriptional i mua o ka tunicamycin.Hoʻopaʻa ʻo Melatonin i ka ʻōlelo COX-2 i hoʻokomo ʻia i ka tunicamycin i loko o nā pūnaewele MDA-MB-231.Eia kekahi, hoʻonui i ka hana COX-2 me ka hoʻohana ʻana i ka COX-2 inhibitor, NS398, hoʻonui i ka apoptosis i hoʻokomo ʻia i ka tunicamycin.ʻO ka mea mahalo, ʻaʻole pili kēia mau hopena me nā ala hōʻailona melatonin receptor.ʻAʻole i hoʻohuli ʻia ka hopena o ka melatonin pertussis toxin (he mea hoʻopaneʻe Gi protein maʻamau) a i ʻole luzindole (he mea kūʻē ʻole melatonin receptor antagonist).Eia kekahi, ua pale ka melatonin i ka hana transcriptional NF-κB i hoʻokomo ʻia i ka tunicamycin, p65 nuclear translocation, a me p38 MAPK act ivation.ʻO ka hoʻopaʻa ʻana i ka p38 MAPK i hoʻopili ʻia me Melatonin i hoʻemi i ka paʻa COX-2 mRNA.Hoʻohui pū ʻia, hōʻike kā mākou hopena i ka hoʻonui ʻana o ka melatonin i ka hana antitumor ma o ka hoʻoponopono ʻana i ka ʻōlelo Bim a me ka hoʻoponopono iho o ka ʻōlelo COX-2 i loko o nā cell MDA-MB-231 i mālama ʻia tunicamycin.