Doxorubicin hydrochloride CAS:25316-40-9 99% ʻAlani-ʻulaʻula Crystalline pauka
| Helu Helu | XD90367 |
| inoa mea kūʻai | ʻO Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| ʻĀpana Molekala | C27H29NO11·HCl |
| Kaumaha Molecular | 579.98 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 29419000 |
Huahana Huahana
| WaiMaʻiʻo | ≤ 4.0% |
| pH | 4.0-5.5 |
| Ka hikiwawe | Hiki ke hoʻoheheʻe ʻia i loko o: wai, methanol a me isotonic NaCl(aq).ʻAʻole hiki ke hoʻoheheʻe ʻia i ka chloroform a me nā mea hoʻoheheʻe organik ʻē aʻe. |
| Na mea pili | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Hoʻāʻo | 99% |
| Nā mea hoʻoheheʻe koena | Acetone a me ka waiʻona: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| ʻO nā mea haumia ʻē aʻe | ≤ 0.5% |
| Huina paumaele | ≤ 2.0% |
| Crystallinity | Kūlike me ka USP |
| Ka nana aku | ʻAlani-ʻulaʻula Crystalline pauda |
| ʻIkepili | HPLC |
ʻO ka poʻe maʻi me ka P-glycoprotein a me ka HER2/neu (HER2) receptor-overexpressing maʻi kanesa maʻamau loaʻa nā hopena lapaʻau maikaʻi ʻole.Eia nō naʻe, ʻaʻohe mea kūʻai aku i nā laina kelepona maʻi maʻi umauma he HER2/P-glycoprotein double-positive, e kaupalena ana i ka noiʻi ʻana ma kēia kahua. maʻi maʻi ʻaʻai laina ma o ka hoʻololi paʻa o ka ATP-binding cassette (ABC) subfamily B lālā 1 (ABCB1) gene e hoʻopili ana i ka P-glycoprotein. ʻOi aku ka kiʻekiʻe o nā pae hōʻike gene ABCB1 ma hope o ka hoʻololi ʻana, i alakaʻi ʻia i ka piʻi ʻana o ka P-glycoprotein he 40 mau manawa. hōʻike.ʻO ka mea mahalo, ʻo ka hoʻololi ʻana o ABCB1 i alakaʻi i kahi piʻi iki o ka HER2 gene a me nā pae hōʻike protein.ʻO ka hoʻololi ʻana o ABCB1 i hoʻonui nui i nā pae hōʻike P-glycoprotein. ʻO ke ʻano i hoʻohana ʻia ma ʻaneʻi no ka hoʻomohala ʻana i kēia laina kelepona ua kūpono ia no ka hoʻokomo wikiwiki ʻana o ka P-glycoprotein-mediated drug resistance i hoʻohālikelike ʻia me nā ʻano hana hou.ʻO ka hōʻike in vitro cytotoxicity hōʻike i kēia laina kelepona he kūʻē kūʻē i kahi ākea o nā mea hana chemotherapeutic.
