GSSG Cas: 27025-41-8 ʻO ka pauka crystalline keʻokeʻo
| Helu Helu | XD90229 |
| inoa mea kūʻai | GSSG |
| CAS | 27025-41-8 |
| ʻĀpana Molekala | C20H32N6O12S2 |
| Kaumaha Molecular | 612.631 |
| Nā kikoʻī mālama | 2 a 8 °C |
| Kānāwai Kūʻai Kūlike | 2930909899 |
Huahana Huahana
| Kahuli kiko'ī | -96 a hiki i -106 |
| Nā metala kaumaha | 10ppm max |
| AS | 2ppm max |
| Nalo ma ka maloo | 15.0% ka nui. |
| Maemae | 95% min |
| Koena ma ka Ignition | 0.5% ka nui |
| Ka nana aku | ʻO ka pauka kristal keʻokeʻo |
| Hoʻāʻo | 99% |
ʻO ka Hepatotoxicity o nā moho lāʻau lapaʻau kekahi o nā hopohopo nui i ka nānā ʻana i ka lāʻau lapaʻau i ka ʻike mua ʻana i ka lāʻau lapaʻau.ʻO ka ʻike ʻana i ke koʻikoʻi o ka hepatic oxidative hiki ke lilo i mea hōʻailona mua o ka hepatotoxicity a me nā pōmaikaʻi o ke koho ʻana i ka lāʻau.ʻO ka glutathione (GSH) a me ka glutathione disulfide (GSSG), ma ke ʻano he mea nui o ka intracellular redox regulatory couples, he kuleana koʻikoʻi i ka pale ʻana i nā cell mai ke koʻikoʻi oxidative i kumu ʻole ʻia ma waena o nā prooxidants a me nā antioxidants.Ua hoʻohana ʻia ka hoʻoholo nui o nā lakio GSSG/GSH a me nā manaʻo o GSH a me GSSG e hōʻike i ke koʻikoʻi oxidative i nā cell a me nā kiko.I loko o kēia haʻawina, ua hoʻāʻo mākou i ka hiki ke hoʻohana i ka biliary GSSG/GSH ratios ma ke ʻano he biomarker e hōʻike i ke koʻikoʻi oxidative hepatic a me ka lāʻau make.ʻEhā mau pūhui i ʻike ʻia e hoʻololi i nā pae GSH a me GSSG i hoʻāʻo ʻia ma kēia haʻawina.Hāʻawi ʻia ka diquat (diquat dibromide monohydrate) a me ka acetaminophen i nā ʻiole.Hāʻawi ʻia ka paraquat a me ka tert-butyl hydroperoxide i nā ʻiole e hoʻololi i ka biliary GSH a me GSSG.Ua helu ʻia ka biliary GSH a me GSSG me ka hoʻohana ʻana i nā pihi calibration i hoʻomākaukau ʻia me ka bile artificial e helu i kekahi hopena bile matrix i ka loiloi LC-MS a e pale aku i ka hoʻopili ʻana o GSH endogenous a me GSSG.Me nā hiʻohiʻona ʻehā (i nā ʻiole a me nā ʻiole) o nā loli i hoʻokomo ʻia i ka lāʻau i nā kinetics o ka biliary GSSG/GSH ratios, ua hōʻike kēia haʻawina i ka hiki ke hoʻomohala i kahi papa kuhikuhi pane ʻike e pili ana i ka biliary GSSG/GSH ratios no ka wānana ʻana i ke kaumaha oxidative hepatic.
