L-Tryptophan Cas: 73-22-3 99% ʻO ka pauka keʻokeʻo
| Helu Helu | XD90295 |
| inoa mea kūʻai | L-Tryptophan |
| CAS | 73-22-3 |
| ʻĀpana Molekala | C11H12N2O2 |
| Kaumaha Molecular | 204.22518 |
| Nā kikoʻī mālama | Ambient |
| Kānāwai Kūʻai Kūlike | 29339980 |
Huahana Huahana
| Hoʻāʻo | 99% min |
| Ka nana aku | Pauda keʻokeʻo |
| Papa | USP32 |
| Kahuli kiko'ī | -29.4 a i -32.8 |
| pH | 5.5 a 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Nalo ma ka maloo | <0.3% |
| Koena ma ka Ignition | 0.1% ka nui |
| Cl | 0.05% ka nui |
ʻO Indoleamine 2,3-dioxygenase (IDO1) a me tryptophan 2,3-dioxygenase (TDO) ʻelua mau enzyme ʻokoʻa ʻē aʻe i loaʻa i kahi mahele ʻokoʻa a me nā kuleana physiological, akā ua hoʻololi ʻelua i ka huli ʻana o tryptophan i N-formylkynurenine (NFK).Ua hōʻoia ʻia ʻo IDO1 ma ke ʻano he lāʻau lāʻau liʻiliʻi liʻiliʻi no ka maʻi kanesa, ʻoiai nā haʻawina preclinical e hōʻike ana he TDO paha ke kumu no ka maʻi immunotherapy a me ka maʻi neurodegenerative.Ua hoʻomohala mākou i kahi hōʻike hōʻike kiʻekiʻe no IDO1 a me TDO e pili ana i kahi noiʻi kemika hou, NFK Green, e hoʻopili pololei me NFK e hana i kahi molekala fluorescent ʻōmaʻomaʻo me ka lōʻihi hawewe excitation o 400 nm a me kahi hawewe hoʻokuʻu o 510 nm.Hāʻawi mākou i ka hoʻohālikelike ʻaoʻao mua o kekahi mau mea paʻi paʻi ʻia o IDO1 a me TDO a hōʻike i ka preclinical IDO1 inhibitor Compound 5l e hōʻike ana i ka cross-reactivity koʻikoʻi me TDO, ʻoiai ua hōʻoia ʻia ka pili pili o nā mea paʻi paʻi ʻē aʻe.Ua hōʻike ʻia ke kūpono no ka nānā ʻana i nā hoʻokolohua kiʻekiʻe ma ka nānā ʻana i kahi waihona o 87,000 mau mea kemika ma 384- a i ʻole 1536-well format.ʻO ka hope, hōʻike mākou e hiki ke hoʻohana ʻia ka assay e ana i ka hiki o nā cell e metabolize tryptophan a me ke ana ʻana i ka mana cellular o IDO1 a me TDO inhibitors.
